Application of spleen-strengthening vital energy-nourishing mass-eliminating formula in preparing renoprotection medicaments after chemotherapy

A technology for strengthening the spleen, nourishing the spleen, and kidney function. It can be used in drug combinations, pharmaceutical formulations, and plant raw materials. It can solve problems such as toxicity and limit application, and achieve the effects of reducing cell apoptosis and protecting kidney function.

Inactive Publication Date: 2014-11-05
JIANGSU PROVINCIAL HOSPITAL OF TCM
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Problems solved by technology

[0002] Cisplatin is a commonly used chemotherapeutic drug in clinical practice. It has a good curative effect on a variety of malignant tumors, and its curative effect is proportional to the dose within a certain range. However, the toxicity of cisplatin greatly limits its application.

Method used

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  • Application of spleen-strengthening vital energy-nourishing mass-eliminating formula in preparing renoprotection medicaments after chemotherapy
  • Application of spleen-strengthening vital energy-nourishing mass-eliminating formula in preparing renoprotection medicaments after chemotherapy
  • Application of spleen-strengthening vital energy-nourishing mass-eliminating formula in preparing renoprotection medicaments after chemotherapy

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experiment example

[0017] 1 Materials and Instruments

[0018] 1.1 Animals and feeding environment:

[0019] BALB / c mice, 40, male and female, 10-12 weeks old, weighing 18-22g; raised in an SPF environment, regularly irradiated with ultraviolet rays indoors, and strictly disinfected cages, bedding, and drinking water.

[0020] 1.2 Drugs and reagents:

[0021] Jianpi Yangzheng Xiaozheng Recipe consists of Codonopsis 15g, Stir-fried Atractylodes macrocephala 10g, Poria cocos 10g, raw barley 20g, angelica 10g, Chinese yam 15g, woody fragrance 10g, white peony root 10g, tangerine peel 6g, sarsaparilla 30g, stone see wear 30g, broiled Composition of licorice 3g, medicine provided by Jiangsu Provincial Hospital of Traditional Chinese Medicine. Add 10 times the amount of double distilled water to soak the above medicine for 30 minutes, boil it until it boils, then cook on low heat for 30 minutes, pour out the liquid medicine, add 5 times the amount of double distilled water, and cook on low heat for ...

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Abstract

The invention discloses an application of a spleen-strengthening vital energy-nourishing mass-eliminating formula in preparing renoprotection medicaments after chemotherapy, and particularly relates to an application in preparing renoprotection medicaments after cis-platinum chemotherapy. According to the application, the spleen-strengthening vital energy-nourishing mass-eliminating formula and chemotherapeutic medicaments are combined, a PI3K / AKT pathway is activated by virtue of the spleen-strengthening vital energy-nourishing mass-eliminating formula, the phosphorylation level of PI3K and AKT can be increased, and the renal tubular epithelial cell apoptosis can be reduced, so that the medicaments are capable of protecting renal functions after cis-platinum chemotherapy.

Description

technical field [0001] The invention belongs to the new application of a compound combination of traditional Chinese medicines, in particular to the application of a prescription for invigorating the spleen and nourishing Zhengxiaozheng in the preparation of drugs for protecting kidney function after chemotherapy. Background technique [0002] Cisplatin is a commonly used chemotherapeutic drug in clinical practice. It has a good curative effect on various malignant tumors, and its curative effect is proportional to the dose within a certain range. However, the toxicity of cisplatin limits its application to a great extent. Since cisplatin is mainly excreted through the kidneys after entering the human body, its renal toxicity is particularly obvious. When cisplatin is used in large doses or continuously, it can cause irreversible damage to the renal tubules, leading to renal failure or even death in severe cases. Modern studies have confirmed that the pathogenesis of cispla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/8994A61P13/12
Inventor 吴坚邹玺张星星刘沈林陈敏
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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