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A kind of self-dissolving paste-like debridement glue and radiation preparation method thereof

A self-dissolving, wound technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of limited application range and action time, and achieve the effect of accelerating wound healing, keeping wound moist and easy to clean

Active Publication Date: 2016-08-17
北京同威新材技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it can only cover the surface of shallow wounds, and alginate is only a coating, and its application range and action time are limited

Method used

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  • A kind of self-dissolving paste-like debridement glue and radiation preparation method thereof
  • A kind of self-dissolving paste-like debridement glue and radiation preparation method thereof
  • A kind of self-dissolving paste-like debridement glue and radiation preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 8g of gelatin / sodium carboxymethylcellulose / propylene glycol alginate / carbomer with a mass ratio of 2:1:2:3 and dissolve it in 92g of purified water with a balance for initial mixing at a stirring speed of 500r / min. Stirring time 40min, until dissolved evenly. Raise the temperature to 60°C, transfer to the mixer, the mixing speed is 3000r / min, and the mixing time is 40min; vacuum defoaming is carried out after homogenization, the defoaming speed is 3000r / min, the vacuum degree is 0.4Mpa, and the defoaming time is 20min. The defoamed solution was sealed in a fixed container and irradiated with gamma rays at a dose of 20 kGy to obtain self-dissolving paste-like debridement glue.

Embodiment 2

[0033]Weigh 8g of gelatin / sodium carboxymethyl cellulose / polygonatum polysaccharide / lectin with a mass ratio of 2:3:2:1 and dissolve it in 92g of purified water for initial mixing with a stirring speed of 500r / min and a stirring time of 30min until uniformly dissolved. Raise the temperature to 40°C, transfer to the mixer, the mixing speed is 2000r / min, and the mixing time is 30min; after homogenization, vacuum defoaming is performed, the defoaming speed is 2000r / min, the vacuum degree is 0.6Mpa, and the defoaming time is 20min. The defoamed solution was sealed in a fixed container and irradiated with gamma rays at a dose of 30 kGy to obtain a self-dissolving paste-like debridement gel.

Embodiment 3

[0035] Use a balance to weigh 9g of chitosan / gelatin / carrageenan powder with a mass ratio of 4:3:2 and dissolve it in 91g of purified water for initial mixing. The temperature of the water bath is 60°C, the stirring speed is 400r / min, and the stirring time is 60min until it dissolves. uniform. Transfer to a blender, the mixing speed is 4000r / min, and the mixing time is 30min; after homogenization, put it into a test tube for degassing by centrifugation, the degassing speed is 1000r / min, and the degassing time is 10min. The seal of the test tube after centrifugal defoaming was irradiated with an electron beam, and the irradiation dose was 20 kGy, to obtain a self-dissolving paste-like debridement gel.

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PUM

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Abstract

The invention relates to self-dissolving pasty wound-cleaning gel. After being prepared, the self-dissolving pasty wound-cleaning gel can be squeezed out and is suitable for a skin area at different depths, especially for a relatively deep skin area which cannot be reached by a membrane or a paster as well as various wound surfaces of irregular shapes; the wound-cleaning gel can be used for sufficiently absorbing percolate on the wound surfaces and dissolving necrotic cells, tissues and deposited pigments in the wound surfaces. The invention further provides a preparation method of the self-dissolving pasty wound-cleaning gel. The preparation method comprises the following steps of sufficiently dissolving high polymer materials, stirring, de-foaming and finally carrying out irradiation cross-linking.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a medical debridement glue, and more specifically to an autodissolving paste-like debridement glue and a radiation preparation method thereof. Background technique [0002] Clinically, in order to protect various wounds caused by burns, trauma, surgery, infection, etc., remove foreign matter and necrotic tissue on the wound, control wound infection, and maintain a moist environment on the wound, various treatment methods and products have been used, but the existing Therapeutic effects of treatments and products are often unsatisfactory. Debridement is a critical step in wound bed preparation. Commonly used debridement methods are: surgical debridement, mechanical debridement, enzymatic debridement, autolytic debridement. Surgical debridement refers to the use of surgical instruments to remove necrotic tissue, and the patient needs to endure the pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/32
Inventor 许零宋雅娜
Owner 北京同威新材技术有限公司