Method for measuring content of carbonyl compound in electronic tobacco juice by adopting direct derivation/high performance liquid chromatography

A high-performance liquid chromatography, electronic cigarette liquid technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of no relevant reports on carbonyl compounds, and achieve good repeatability and recovery rate, fast operation, and high sensitivity Effect

Active Publication Date: 2014-11-12
CHINA TOBACCO ZHEJIANG IND
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Problems solved by technology

However, there is no relevant report on the research on carbonyl compounds in e-cigarette liquid

Method used

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  • Method for measuring content of carbonyl compound in electronic tobacco juice by adopting direct derivation/high performance liquid chromatography
  • Method for measuring content of carbonyl compound in electronic tobacco juice by adopting direct derivation/high performance liquid chromatography
  • Method for measuring content of carbonyl compound in electronic tobacco juice by adopting direct derivation/high performance liquid chromatography

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Embodiment Construction

[0018] The present invention is further described by the following specific examples, but does not limit the present invention.

[0019] A method for determining the content of carbonyl compounds in e-cigarette liquid by ion chromatography. The test process is to first add acidified 2,4-dinitrophenylhydrazine to the acetonitrile solution of the e-cigarette liquid sample for derivation, and then add 2% Pyridine / acetonitrile (V / V) solution extraction, the extract was filtered through a 0.45 μm aqueous microporous membrane, and then entered into a high-performance liquid chromatograph for determination, and the external standard method was used for quantitative analysis.

[0020] Main instruments and reagents

[0021] Main instruments: Agilent HPLC 1260, equipped with quaternary gradient pump, autosampler, Chromeleon 6.8 chromatographic workstation (Agilent, USA); ultrapure water instrument (Millipore, USA); HY-8 speed-adjustable oscillator (Changzhou Guohua Electric Co., Ltd.)....

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Abstract

The invention discloses a method for measuring the content of a carbonyl compound in electronic tobacco juice by adopting a direct derivation/high performance liquid chromatography. The method comprises the steps of firstly adding an acidified acetonitrile solution of 2,4-dinitrophenylhydrazine for derivation, extracting by adding 2% pyridine/acetonitrile (V/V) solution to obtain an extracting solution, after filtering the extracting solution by using a 0.45mu m water-phase microfiltration membrane, measuring the filtered extracting solution in a high performance liquid chromatograph, and carrying out quantitative analysis by adopting an external standard method. A linear relation of 2,4-dinitrophenylhydrazone compounds of formaldehyde, acetaldehyde and acraldehyde in a linear range is good (R<2> is more than 0.9999); limits of detection (LOD) are respectively 1.76ng/mL, 1.09ng/mL and 2.40ng/mL, an average recovery rate range of three labeling levels is 93.8 percent to 108.6 percent, and the relative standard deviation (RSD) is less than 4.34 percent, so that the method is high in sensitivity and good in repeatability and recovery rate.

Description

technical field [0001] The invention relates to the technical field of physical and chemical inspection of electronic cigarette products, in particular to a method for measuring the content of carbonyl compounds in electronic cigarette liquid by using high performance liquid chromatography. Background technique [0002] E-cigarettes, also known as electric atomized cigarettes, are electronic devices that deliver nicotine to the respiratory system by means of electronic heating. The e-liquid in the pod is mainly propylene glycol, glycerin or polyethylene glycol containing nicotine. In order to improve the taste, it is supplemented with various flavors to prepare various flavors to meet the needs of different smokers. E-cigarettes are a new way of smoking nicotine, which can reduce the harm of smoking traditional cigarettes to a certain extent, but whether the chemicals contained in the cartridges of e-cigarettes will bring new hazards to the human body or not Sex is undeterm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 史春云周国俊卢昕博肖卫强袁凯龙刘金莉夏倩王骏黄华
Owner CHINA TOBACCO ZHEJIANG IND
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