A kind of fat emulsion injection containing levocarnitine

A technology of injection and fat emulsion, which is applied in the field of medicine, can solve the problems of high hardware cost, high personnel training cost, difficulty in ensuring drug safety, and affecting the stability of preparations, so as to help rapid metabolism and absorption, reduce the incidence of adverse reactions, and avoid adverse reactions. The effect of the reaction

Active Publication Date: 2017-10-10
XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, levocarnitine is temporarily added to TPN during intravenous injection, but the mixing configuration of intravenous injection drugs requires a strict aseptic preparation studio to avoid bacterial contamination of the solution during the preparation process, while the nutrient solution is The rapid reproduction of bacteria provides the best conditions. Once the bacteria are contaminated during the preparation, the consequences after intravenous infusion are disastrous. Due to the high cost of hardware and personnel training, only a small number of hospitals in the country can meet the preparation environment conditions required by the state.
At the same time, it is still doubtful whether the temporary addition of levocarnitine to TPN will affect the stability of the preparation, so this method is not conducive to the promotion of the drug, and it is difficult to ensure the safety of the drug.

Method used

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  • A kind of fat emulsion injection containing levocarnitine
  • A kind of fat emulsion injection containing levocarnitine
  • A kind of fat emulsion injection containing levocarnitine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Fat emulsion containing 1% levocarnitine

[0058]

[0059]

[0060] Preparation process: The whole production process is carried out under nitrogen protection:

[0061] a. Take 12g of egg yolk lecithin and 100g of soybean oil and heat and stir to dissolve completely to obtain an oil phase;

[0062] b. Take 10g of levocarnitine and 22.5g of glycerol, add appropriate amount of water, stir and dissolve to obtain the water phase;

[0063] c. Under the stirring of a high-speed shearing machine, slowly drop the above-mentioned oil phase into the aqueous phase solution, and stir for 15 minutes to obtain colostrum. The stirring speed of the shearing machine is 8000 rpm, and the stirring temperature is 70 ° C;

[0064] d. The colostrum is homogenized by high pressure for 7-8 times, the pressure is 100MPa, and the pH is adjusted to 6.8. Subpackage, pass through nitrogen, seal, and sterilize at 121°C for 15 minutes. After passing the light inspection, pack. Sto...

Embodiment 2

[0065] Example 2 Fat Emulsion Injection Containing 0.5% Levocarnitine

[0066]

[0067] The preparation process is the same as in Example 1.

Embodiment 3

[0068] Example 3 Fat Emulsion Injection Containing 3% Levocarnitine

[0069]

[0070] The preparation process is the same as in Example 1.

[0071] (2) Preparation of Levocarnitine-containing Fat Emulsion Injection with Different Oils for Injection and Their Different Contents

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PUM

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Abstract

The invention discloses a fat emulsion injection containing levocarnitine and a preparation method thereof. The preparation components include levocarnitine, oil for injection, phospholipid as an emulsifier, glycerin as an osmotic pressure regulator, and Appropriate amount of water for injection and pH regulator. The fat emulsion injection containing levocarnitine of the present invention can not only improve the metabolism of fat emulsion in the body, make the fat emulsion fully utilized in the body, but also inhibit the concentration of lipids in the blood from being too high, thereby reducing hyperlipidemia and levocarnitine The incidence of a series of adverse reactions that Nitin deficiency may bring.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a fat emulsion injection and a preparation method thereof, in particular to a fat emulsion injection containing levocarnitine and a preparation method thereof. Background technique [0002] Fat emulsion is a uniform and stable oil-in-water emulsion, which has been widely used clinically as an intravenous nutrition agent. It can provide energy and essential fatty acids for the body, and is used to supplement energy and essential fatty acids in parenteral nutrition. , to prevent and treat human essential fatty acid deficiency, provide essential fatty acids for patients who cannot maintain and restore normal essential fatty acid levels through oral routes, and provide high energy supplements for patients who are weak after surgery and cannot absorb nutrients through the digestive tract. [0003] With the clinical use of fat emulsion as an intravenous nutrient, its adverse reactions h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/205A61K36/48A61K36/32A61K9/107A61P3/02
Inventor 王汝涛安龙赵熠陈涛
Owner XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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