A kind of fat emulsion injection containing levocarnitine

Abstract

The invention discloses a fat emulsion injection containing levocarnitine and a preparation method thereof. The preparation components include levocarnitine, oil for injection, phospholipid as an emulsifier, glycerin as an osmotic pressure regulator, and Appropriate amount of water for injection and pH regulator. The fat emulsion injection containing levocarnitine of the present invention can not only improve the metabolism of fat emulsion in the body, make the fat emulsion fully utilized in the body, but also inhibit the concentration of lipids in the blood from being too high, thereby reducing hyperlipidemia and levocarnitine The incidence of a series of adverse reactions that Nitin deficiency may bring.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a fat emulsion injection and a preparation method thereof, in particular to a fat emulsion injection containing levocarnitine and a preparation method thereof. Background technique [0002] Fat emulsion is a uniform and stable oil-in-water emulsion, which has been widely used clinically as an intravenous nutrition agent. It can provide energy and essential fatty acids for the body, and is used to supplement energy and essential fatty acids in parenteral nutrition. , to prevent and treat human essential fatty acid deficiency, provide essential fatty acids for patients who cannot maintain and restore normal essential fatty acid levels through oral routes, and provide high energy supplements for patients who are weak after surgery and cannot absorb nutrients through the digestive tract. [0003] With the clinical use of fat emulsion as an intravenous nutrient, its adverse reactions h...

AI Technical Summary

Problems solved by technology

In this method, levocarnitine is temporarily added to TPN during intravenous injection, but the mixing configuration of intravenous injection drugs requires a strict aseptic preparation studio to avoid bacterial contamination of the solution during the preparation process, while the nutrient solution is The rapid reproduction of bacteria provides the best conditions. Once the bacteria are contaminated during the preparation, the consequences after intravenous infusion are disastrous. Due to the high cost of hardware and personnel training, only a small number of hospitals in the country can meet the preparation environment conditions required by the state.

At the same time, it is still doubtful whether the temporary addition of levocarnitine to TPN will affect the stability of the preparation, so this method is not conducive to the promotion of the drug, and it is difficult to ensure the safety of the drug.

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