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A kind of gel that reduces the concentration of potassium ion in stock blood and its preparation method and application

A technology of ion concentration and gel, which is applied in the field of blood transfusion medicine, can solve the problems of staying and not yet, and achieve the effect of easy preparation and prevention of hyperkalemia hazards

Active Publication Date: 2017-07-07
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, the research on blood potassium ion concentration still stays at the stage of detection of blood potassium ion concentration. For example, patent CN1896271B discloses a method for serum potassium ion enzymatic determination reagent, and patent CN101717814A discloses a method for measuring Serum and plasma potassium ion concentration test kits; in the existing published literature at home and abroad, there is no relevant report on the technology for reducing the potassium ion concentration in stock blood

Method used

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  • A kind of gel that reduces the concentration of potassium ion in stock blood and its preparation method and application

Examples

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Effect test

Embodiment 1

[0036] The steps of preparing a kind of sodium polystyrene sodium sulfonate gel for reducing stock blood potassium ion concentration are as follows:

[0037] Take 10.0g of sodium polystyrene sulfonate, 1.0g of sodium chloride and 2.5g of agarose gel, and dilute to 100ml of water; heat to 100°C and maintain for 3 seconds, repeat heating 3 times, until the temperature drops to 60°C Pour into a square template and wait for it to solidify naturally to obtain the desired gel.

Embodiment 2

[0039] The steps of preparing a kind of sodium polystyrene sodium sulfonate gel for reducing stock blood potassium ion concentration are as follows:

[0040] Take 15.0g of sodium polystyrene sulfonate, 1.0g of sodium chloride and 2.0g of agarose gel, and dilute to 100ml of water; heat to 100°C and maintain for 5 seconds, repeat heating 4 times, until the temperature drops to 70°C Pour into a square template and wait for it to solidify naturally to obtain the desired gel.

Embodiment 3

[0042] The steps of preparing a kind of sodium polystyrene sodium sulfonate gel for reducing stock blood potassium ion concentration are as follows:

[0043] Take 5.0g of sodium polystyrene sulfonate, 0.6g of sodium chloride and 0.5g of agarose gel, and dilute to 100ml of water; heat to 100°C and maintain for 4 seconds, repeat heating twice, until the temperature drops to 55°C Pour into a square template and wait for it to solidify naturally to obtain the desired gel.

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Abstract

The invention discloses a gel for reducing the potassium ion concentration in stock blood and its preparation method and application. The gel comprises: 3.0-25.0 parts by weight of sodium polystyrene sulfonate, 0.1-1.5 parts by weight of sodium chloride, 0.1-2.5 parts by weight of auxiliary gel and solvent; the steps of the preparation method include taking sodium polystyrene sulfonate, sodium chloride, auxiliary gel and solvent, and set the volume to 100ml water; repeat heating 2-6 times, When the temperature drops to 55-70°C, pour it into the template and solidify to obtain the desired gel. The gel of the present invention can be added to the red blood cell preservation solution, stored in a blood bag and sealed to prepare a red blood cell preservation device, and then added with fresh red blood cells to be preserved. The gel of the invention can significantly reduce the potassium ions of stored red blood cells, and can effectively prevent hyperkalemia caused by transfusion of stored blood; the gel is easy to prepare and has a special stabilizing effect.

Description

technical field [0001] The invention relates to the technical field of blood transfusion medicine, in particular to a method for preserving and processing blood products, in particular to a gel for reducing the concentration of potassium ions in stored blood and its preparation method and application. Background technique [0002] At present, most patients who need blood transfusion need to supplement red blood cells, so there are many types of red blood cell preparations, mainly including: suspended red blood cells, plasma-less blood, concentrated red blood cells, washed red blood cells, red blood cells with reduced white blood cells, etc. Usually, the erythrocyte preparation is preserved with CPAD preservation solution, and the preservation period at a temperature of 4°C is 35 days. [0003] However, in the whole blood stored for a long time, the red blood cells will age and rupture, and the potassium ions in the cells will be released into the blood, resulting in an exces...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/36A61K9/06A61K35/18A61P7/06
Inventor 朱长太李志强黎勤云陈琼杜玉珍马可邓志峰
Owner SHANGHAI SIXTH PEOPLES HOSPITAL