Hemostatic crosslinked composition, its preparation method and use, and hemostatic antistick material prepared from hemostatic crosslinked composition

A cross-linked composition and anti-adhesion technology, applied in the field of medical materials, can solve the problems of poor mechanical properties and flexibility, unable to achieve ideal hemostasis and anti-adhesion effect, poor modified starch, etc., and achieve good mechanical properties and in vivo degradation time. control, the effect of broad market application prospects

Active Publication Date: 2014-12-17
成都吉泰医疗器械有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, modified starch has poor film-forming (or sponge) properties, poor mechanical properties and flexibility, so its clinical application is also limited.
[0006] In short, none of the hemostatic and anti-adhesion materials currently on the market can achieve the ideal hemosta

Method used

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  • Hemostatic crosslinked composition, its preparation method and use, and hemostatic antistick material prepared from hemostatic crosslinked composition
  • Hemostatic crosslinked composition, its preparation method and use, and hemostatic antistick material prepared from hemostatic crosslinked composition
  • Hemostatic crosslinked composition, its preparation method and use, and hemostatic antistick material prepared from hemostatic crosslinked composition

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preparation example Construction

[0057] In one embodiment of the preparation method according to the present invention, raw materials such as polysaccharide and gelatin can be dissolved in water to form an aqueous solution and then mixed and cross-linked, or they can be added to water in any order to form a solution for cross-linking. In a preferred embodiment of the present invention, acyl or carboxyl-containing polysaccharides, gelatin, cross-linking agent and activator are respectively dissolved in water to form a solution, then the resulting aqueous solution is mixed for cross-linking, and the temperature for preparing the aqueous solution can be 10 ~40°C, each raw material is dissolved in water and then fully stirred to form a uniform aqueous solution, otherwise the effect of crosslinking may be affected, and the stirring time can be 0.1 to 5 hours.

[0058] In one embodiment of the preparation method according to the present invention, the temperature when the raw materials are mixed and cross-linked can...

Embodiment 1

[0079] Example 1 Preparation of hemostatic cross-linked composition protoplasm

[0080]Put 200mg of sodium carboxymethyl starch in a 50ml clean beaker, dissolve it in 6ml of deionized water, and adjust the pH of the solution to between 4 and 5 with 0.1N HCl. Dissolve 100 mg of gelatin in 5 ml of deionized water and stir at 40° C. for 2 hours to prepare a homogeneous gelatin solution. Add dropwise the mixed aqueous solution 0.6ml of crosslinking agent / activator in the carboxymethyl starch solution under stirring, contain the carbodiimide (EDC) of 40mg and the N-hydroxysuccinimide (NHS) of 20mg in this mixed solution . After stirring the above solution for 5 minutes, add the prepared gelatin solution, control the pH of the resulting mixed solution to be between 4 and 5, and stir in a water bath at 40°C for 1 hour to fully cross-link the polysaccharide and gelatin in the solution. Wash by dialysis to remove small molecular substances such as cross-linking agent in the cross-lin...

Embodiment 2

[0082] Example 2 Preparation of hemostatic cross-linked composition protoplasm

[0083] Dissolve 0.5g sodium carboxymethylcellulose in 50ml distilled water to prepare a solution. Dissolve 1g of gelatin in 50ml of distilled water to make a gelatin solution. Under stirring at room temperature, add dropwise 3ml of a mixed aqueous solution of crosslinking agent / activator to the carboxymethylcellulose solution, which contains 100mg of carbodiimide (EDC) and 50mg of N-hydroxysuccinimide (NHS ). After stirring the above solution for 5 minutes, add the prepared gelatin solution, and stir in a water bath at 40° C. for 1 hour, so that the polysaccharide and gelatin in the solution are fully cross-linked. Washing by dialysis to remove small molecular substances such as cross-linking agents in cross-linking to obtain cross-linked puree.

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Abstract

The invention provides a hemostatic crosslinked composition. The hemostatic crosslinked composition is prepared from gelatin and acyl- or carboxyl-containing polysaccharide. The invention also provides a preparation method and use of the hemostatic crosslinked composition. The invention also provides a hemostatic antistick material containing the hemostatic crosslinked composition. The hemostatic crosslinked composition has the characteristics of a hemostatic gelatin product and a hemostatic polysaccharide product. Compared with the existing hemostatic products, the hemostatic crosslinked composition obviously improves absorption properties, haemostasis and blood clotting performances and degradability. The hemostatic antistick material provided by the invention has the advantages of high haemostasis efficiency and controllable internal-degradation time, can satisfy requirements on hemostatic materials and especially on medical hemostatic antistick materials, and has a wide market application prospect.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a hemostatic crosslinking composition, its preparation method and application, and a hemostatic and anti-adhesion material obtained therefrom. Background technique [0002] Hemorrhage caused by trauma or surgery may be life-threatening due to excessive blood loss within a few minutes, and it is too late for treatment. It is an important cause of daily accidental death, especially in the neck, armpit, groin and other limbs and trunk. Hemostasis at the junction is most difficult. These parts are rich in blood vessels, and conventional compression bandage hemostasis methods such as tourniquets cannot achieve a good hemostatic effect. In addition, the bleeding problem in surgical operations is also an important reason for surgical failure, especially for operations on brain, liver, spleen, lung, kidney and other substantive organs and tumor lesions, relying solely on traditional mec...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L15/44A61L31/04A61L15/28
Inventor 范冬梅王凝董骧刘慧琴郑诚功
Owner 成都吉泰医疗器械有限公司
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