Medicament reutilization method based on omics data

Abstract

The invention discloses a novel method for medicament reutilization, and particularly relates to a method for integrating data analysis results of human diabetes-associated whole-genome association analysis, proteomics and metabonomics, screening human diabetes-associated risk proteins, exploring information of marking medicaments or clinical experiment medicaments working on the human diabetes-associated risk proteins by combining a medicament development database, and integrating pathogenesis information of human diabetes through a public database. According to the method, 58 marking medicaments or clinical experiment medicaments aiming at other diseases are excavated, and a novel purpose for treating the human diabetes is achieved.

Description

technical field [0001] The invention belongs to the application of a new method of drug reuse, in particular to the treatment of human diabetes by mining some marketed drugs and clinical experimental drugs through clinical omics data. Background technique [0002] Drug repurposing methods, also known as drug repurposing, or repurposing old drugs, have been widely used in discovering new uses of marketed drugs and drugs in clinical trials (Ashburn et al., Nat Rev Drug Discov 2004). Most of the previous successful cases of drug repurposing were discovered by chance (Sardan et al., Brief Bioinform 2011). In recent years, many advances have been made in systematic drug repurposing methods using data from in vitro samples, animal models, and clinical samples, such as comparing the effects of different drugs on the gene expression profile of cells (connectivity map, CMap) (Lamb et al., Science 2006 ), network analysis (Chindelevitch et al., Bioinformatics 2012), computational bio...

AI Technical Summary

Problems solved by technology

Existing drug repurposing methods are only based on in vitro, animal experiment data or gene association

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