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A kind of pterostilbene composition and preparation method thereof

A technology of pterostilbene and a composition, applied in the field of medicine, can solve the problems of low oral bioavailability, no oral preparation of pterostilbene, poor permeability, etc., and achieves improved oral bioavailability, simple preparation method and low cost Effect

Inactive Publication Date: 2016-06-01
郝磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pterostilbene has a good anti-tumor effect, but due to poor water solubility and poor intestinal permeability, the oral bioavailability is very low, and there is no oral preparation of pterostilbene on the market.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Dissolve 0.1 g of L-carnosine in 100 mL of ethanol, then add 0.1 g of sodium stearyl fumarate to obtain a dispersion of the auxiliary material; dissolve 0.1 g of pterostilbene with 50 mL of ethanol to obtain a dispersion of the drug; disperse the dispersion of the auxiliary material and the drug Mix the solution evenly, recover ethanol under vacuum at 40°C, and dry at 40°C for 6 hours to obtain the product.

Embodiment 2

[0014] Dissolve 0.1 g of L-carnosine in 100 mL of ethanol, then add 0.1 g of sodium stearyl fumarate to obtain a dispersion of the auxiliary material; dissolve 0.1 g of pterostilbene with 20 mL of ethanol to obtain a dispersion of the drug; disperse the dispersion of the auxiliary material and the drug The solution was mixed evenly, ethanol was recovered under vacuum at 40°C, and freeze-dried to obtain the product.

Embodiment 3

[0016] Dissolve 0.1 g of L-carnosine in 200 mL of ethanol, then add 0.1 g of sodium stearyl fumarate to obtain a dispersion of the auxiliary material; dissolve 0.1 g of pterostilbene with 100 mL of ethanol to obtain a dispersion of the drug; disperse the dispersion of the auxiliary material and the drug The solution was mixed evenly, ethanol was recovered under vacuum at 30°C, and freeze-dried to obtain the product.

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PUM

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Abstract

The invention provides a pterostilbene composition with relatively high oral bioavailability and a preparation method of the pterostilbene composition. The pterostilbene composition provided by the invention is characterized by containing pterostilbene, sodium stearyl fumarate and L-carnosine, wherein the preferred mass ratio of the pterostilbene to the sodium stearyl fumarate to the L-carnosine is 1: 1: 1. The preparation method of the pterostilbene composition comprises the following steps: dissolving the L-carnosine by using ethyl alcohol, adding the sodium stearyl fumarate to obtain accessory dispersion, dissolving the pterostilbene by using ethyl alcohol to obtain drug dispersion, uniformly mixing the accessory dispersion with the drug dispersion, recovering the ethyl alcohol, and drying to obtain the pterostilbene composition.

Description

technical field [0001] The invention relates to a pterostilbene composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Pterostilbene has a good anti-tumor effect, but due to poor solubility in water and poor intestinal permeability, the oral bioavailability is very low, and there is no oral preparation of pterostilbene on the market. Contents of the invention [0003] The object of the present invention is to provide a pterostilbene composition with high oral bioavailability and a preparation method thereof. [0004] For the purpose of the above invention, the present invention provides the following technical solutions: [0005] The pterostilbene composition of the present invention is characterized in that it contains pterostilbene, sodium stearyl fumarate and L-carnosine; the mass ratio of pterostilbene, sodium stearyl fumarate and L-carnosine is preferably 1:1:1. [0006] The method for pterostilbene ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/09A61K47/12A61K47/42A61P35/00
CPCA61K31/09A61K47/12A61K47/183A61K2300/00
Inventor 郝磊徐云玲魏现娟郝坤葛刚郝霞
Owner 郝磊