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Bubble ejection member and manufacturing method thereof, gas-liquid ejection member and manufacturing method thereof, local ablation device and local ablation method, injection device and injection method

A technology of injection device and component, which is applied to injecting injectors, other methods of inserting foreign genetic materials, injectors, etc., can solve the problems of plasma existence, inability to maintain plasma state for a long time, difficult plasma state, etc.

Active Publication Date: 2017-05-10
JAPAN SCI & TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the conventional plasma technology, it is difficult to make a plasma-generating state exist in the solution, so it is used to generate plasma in the gas near the electrode at one time, and then use the generated plasma to generate plasma containing plasma in the solution. However, it is impossible to maintain the plasma state for a long time, and it is also difficult to move the bubbles while maintaining the plasma state (problem 10, refer to non-patent documents 5 and 6).

Method used

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  • Bubble ejection member and manufacturing method thereof, gas-liquid ejection member and manufacturing method thereof, local ablation device and local ablation method, injection device and injection method
  • Bubble ejection member and manufacturing method thereof, gas-liquid ejection member and manufacturing method thereof, local ablation device and local ablation method, injection device and injection method
  • Bubble ejection member and manufacturing method thereof, gas-liquid ejection member and manufacturing method thereof, local ablation device and local ablation method, injection device and injection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0082] figure 1 (a) shows the manufacturing method 10 of the bubble ejection member having a structure having a cavity at the tip according to Embodiment 1 of the present invention. The bubble ejection member of the present invention is as figure 1 As shown in (a), (1) prepare a hollow insulating material 15; (2) insert a core material 20 formed of a conductive material into the hollow insulating material 15; (3) pull off after applying heat 25; (4 ) through the difference between the viscoelasticity of the insulating material 15 and the core material 20, such as figure 1 As shown in (b), an outer shell portion 16 including a portion extending from the front end of the core material 20 to the insulating material 15 is formed, and a gap 30 is formed by the extended portion of the core material 20 and the outer shell portion 16 .

[0083] The insulating material 15 is not particularly limited as long as it is electrically insulating, and examples thereof include inorganic insu...

Embodiment approach 2

[0093]Hereinafter, Embodiment 2 of the present invention will be described with reference to the drawings. In addition, the same reference numerals in the drawings indicate the same members as those in the first embodiment.

[0094] Figure 6 (a) is a schematic diagram showing an outline of a local ablation method and an injection method using the gas-liquid ejection member of the present invention. In the gas-liquid ejection member of the second embodiment, the outer outer shell portion 21 is formed on the outer side of the outer shell portion 16 of the air bubble ejection member of the first embodiment at a position away from the outer shell portion 16, and In the space 22 formed by the outer shell 16 and the outer shell 21, the injection substance-containing solution 61 is introduced in advance, so that the air bubbles 60 adsorbed by the injection substance-containing solution 61 can be released from the front end of the gas-liquid ejection member. Figure 6 (b) is a diag...

Embodiment approach 3

[0101] Below, refer to the attached Figure 1 Embodiment 3 of the present invention will now be described. Figure 11 It is a figure which shows the outline|summary of the plasma bubble ejection member of this invention.

[0102] Such as Figure 11 As shown, the plasma bubble ejection member includes at least on the substrate: a pair of electrodes 200 formed of conductive materials; a fine flow path (micro flow path) 210, which is used to make the inert gas 205 and the liquid containing plasma the liquid flow of the air bubbles 230; and the liquid flow path 220 connected to the fine flow path 210 on the downstream side of the portion of the fine flow path 210 where plasma is generated. By applying a high-frequency electric pulse to the electrode 200, plasma is generated in the inert gas 205 flowing into the fine flow path through a pump not shown in the figure, and the inert gas containing the plasma flows to the downstream side, and then, through the The fluid force when t...

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Abstract

The present invention provides a device that can be processed locally without being damaged by heat when processing objects such as cells, and can be easily recombined or regenerated after processing, and can introduce injection substances efficiently , and a device for generating bubbles containing plasma. The object to be processed can be processed locally without damage by the local ablation device using a bubble ejection member including: a core material formed of a conductive material; an outer shell, formed of an insulating material, covering the core material, and including a portion extending from a front end of the core material; and a gap formed between the extending portion of the outer profile portion and the front end of the core material between. In addition, by further providing the outer contour portion on the outer periphery of the contour portion, the air bubbles adsorbed by the solution containing the injection substance can be released, and the injection substance can be introduced while performing local ablation of the object to be processed. In addition, it includes a pair of electrodes, which are formed of a conductive material, and are used to generate plasma in an inert gas; a liquid flow path for making a liquid flow; Gas and liquid containing bubbles of inert gas containing plasma flow; the liquid flow path and the fine flow path are connected downstream of the plasma-generating portion of the fine flow path to generate plasma-containing Because the bubbles of the body can maintain the plasma state even in the liquid, the plasma can be used to treat biological tissues.

Description

technical field [0001] The present invention relates to a bubble ejection member and a manufacturing method thereof, a gas-liquid ejection member and a manufacturing method thereof, a local ablation device and a local ablation method, an injection device and an injection method, a plasma bubble ejection member, a treatment device and a treatment method, especially It involves immersing a local ablation device and an injection device in a solution, and releasing micro-nano bubbles generated by applying a high-frequency voltage to the local ablation device and injection device (hereinafter also referred to as when described as "bubbles"), the local ablation method of processing objects such as biological cells with the released air bubbles, and processing the object of processing such as biological cells with the local ablation method simultaneously Injection method in which the injected substance contained in the adsorbed solution is introduced into the object to be processed. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B18/12A61N1/44C12M1/00
CPCA61B17/3203A61M5/30C12N15/87A61M5/2066A61M5/3007A61B2018/00029C12M35/04A61B18/042A61B2018/00601A61B18/12A61N1/44C12M1/00C12N13/00A61B2018/00577
Inventor 山西阳子佐久间臣耶栗木宏树新井史人
Owner JAPAN SCI & TECH CORP
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