siRNA for inhibiting gene expression of s100a8 and application thereof

Abstract

The invention discloses a siRNA for inhibiting gene expression of S100A8 and an application thereof and relates to the field of molecular biology. The sequences of the siRNA for inhibiting gene expression of S100A8 are as follows: the positive-sense strand: 5'-CCAGGAGUUCCUCAUUCUG-3'; the antisense strand: 5'-CAGAAUGAGGAACUCCUGG-3'. The siRNA disclosed by the invention can be used for reducing expression of the gene S100A8 and inhibiting expression of gene MMP7 in a nasopharyngeal carcinoma cell CNE1, so that the migration function of the nasopharyngeal carcinoma cell is weakened. Therefore, the siRNA can be applied to researching drugs for treating nasopharynx cancer.

Description

technical field

[0001] The invention relates to the field of molecular biology, in particular to siRNA for inhibiting the expression of S100A8 gene and its application in inhibiting the migration function of nasopharyngeal carcinoma cell CNE1. Background technique

[0002] Nasopharyngeal carcinoma (Nasopharyngeal carcinoma NPC) is a malignant tumor derived from nasal mucosal epithelial cells, more than 95% of which are undifferentiated carcinomas, with high malignancy, fast growth, and prone to lymph node or blood metastasis. Cancer patients all die from tumor metastasis rather than the primary tumor. In recent years, with the rapid development of molecular biology and technology, the occurrence and development of nasopharyngeal carcinoma and its biological behavior have made great progress. A number of studies have shown that S100A8 and S100A9 are involved in the occurrence and development of tumors. Some studies have used iTRAQ protein quantitative labeling combined with ...

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