Hemostatic and anti-adhesion composite material of hydroxyethyl cellulose system and preparation method thereof

Abstract

The invention discloses a haemostatic anti-adhesion composite material for a hydroxyethyl cellulose system and a preparation method of the composite material. The composite material comprises anti-adhesion fiber yarns and haemostatic powder, wherein the anti-adhesion fiber yarns are interwoven with one another and are prepared from organic polymers with the weight-average molecular weight of 50000-500000; and the haemostatic powder is attached to the outer surfaces of the anti-adhesion fiber yarns and is made of hydroxyethyl cellulose. According to the composite material disclosed by the invention, the haemostatic powder made of the hydroxyethyl cellulose in the composite material is attached to the outside the anti-adhesion fiber yarns which are interwoven with one another and can be rapidly turned into gel to be attached to the surface of a wound, the haemostatic powder is diluted and adsorbed after being completely gelled, the haemostatic effect is good, the haemostatic rate is high, healing of the wound is not influenced, and postoperative adhesions can be effectively reduced. In addition, the blood coagulation is locked in a fibrous membrane formed by interweaving the anti-adhesion fiber yarns, and the wound is further protected.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hemostasis and anti-adhesion composite material of a hydroxyethyl cellulose system and a preparation method thereof. Background technique [0002] After the peritoneum is injured, rubbed, burned, dried, contacted with foreign bodies, and infected, the permeability of blood vessels increases, mediated by histamine to produce inflammatory exudates and fibrin matrix, which can be dissolved by fibrinolysis in vivo Process removal. Normally, fibrinolytic system activity is activated, fibrinolysis, and peritoneal mesothelialization. However, under abnormal conditions such as ischemia caused by surgical trauma, the activity of the fibrinolytic system is inhibited, fibrin forms bridges, and finally adhesions are formed. Postoperative adhesion is one of the important medical problems that has not yet been solved in the field of surgery at home and abroad. Adhesion can no...

AI Technical Summary

Problems solved by technology

Our previous studies have shown that the combination of hemostatic agent and anti-adhesion material can effectively prevent the occurrence of postoperative active bleeding, but for the selection of the amount of hemostatic agent, how to better release it for different wounds and the remaining hemostatic agent in the anti-adhesion film after hemostasis is completed The problem of drug metabolism has not been solved

At the same time, we also combine the use of hemostatic gel and anti-adhesion materials to exert their respective effects, that is, to retain the mechanical strength of the anti-adhesion material and the hemostatic function of the hemostatic gel. The coagulation is locked in the material without inducing fibroblasts to adhere. At the same time, it does not affect the healing of mesothelial cells. Due to the limited adsorption capacity of the spongy body, this compound is only suitable for bleeding with a small amount of bleeding. For wounds where the vision of the wound is blurred and the bleeding point is not obvious, the wound care effect is not obvious.

[0004] Existing studies have shown that powdered hemostatic materials have better water absorption and faster hemostasis than gel and sponge hemostatic materials. However, the rapid hemostasis process of zeolite hemostatic powders will cause the local temperature of the wound to be too high , although starch and polysaccharide hemostatic powder greatly reduce the exothermic phenomenon in the dissolution process, there are also problems such as the spraying range is not easy to control, and the wound surface is difficult to clean after hemostasis. Especially for internal hemostasis, excessive hemostatic powder may induce excessive inflammatory reactions

The hemostatic materials in the prior art are used alone, and it is difficult to use them in combination with other membrane materials or gel materials. Generally, the hemostatic powder is sprayed and then covered with wound protection materials, which cannot avoid the disadvantages of using alone