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Preparation method of totally-substituted thiophene

A fully substituted, thiophene technology, applied in organic chemistry and other directions, can solve the problems of difficult industrial large-scale production, complex reaction steps, lack of practical value, etc., and achieve the effects of simple and easy separation of reaction products, easy operation and low cost.

Inactive Publication Date: 2015-03-04
GUANGDONG UNIV OF PETROCHEMICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented process allows for efficient preparation of full substitution thieno[The technical effect of this new method lies on its simplicity, ease of use, low costs, safety concerns associated with traditional methods, and ability to produce highly pure chemical materials at an affordable price level.

Problems solved by technology

Technological Problem addressed in this patented technical problem involves finding ways to efficiently make full substitution type (C)thioarenes without generating unwanted side effects like excessively expensive starting material for chemical processes.

Method used

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  • Preparation method of totally-substituted thiophene
  • Preparation method of totally-substituted thiophene
  • Preparation method of totally-substituted thiophene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Preparation of fully substituted thiophene compound 2a

[0028] Reaction conditions: Elemental sulfur (3.0 mmol), acetylenic compound 1a (2.0 mmol), KOH (0.2 mmol) and toluene (2.0 mL) were sequentially added to the reactor, and stirred at 100° C. for 3 hours. The obtained mixture was separated by thin layer chromatography (eluent: V petroleum ether: V ethyl acetate = 20:1), the structure of the product was confirmed by NMR and IR to be fully substituted thiophene 2a, and the yield was 84%.

[0029]

Embodiment 2

[0030] Example 2 Preparation of fully substituted thiophene compound 2b

[0031] The fully substituted thiophene compound 2b was prepared from the acetylenic compound 1b, and the reaction conditions were as in Example 1. The structure of the product was confirmed to be fully substituted thiophene 2b by NMR and IR, and the yield was 88%.

[0032]

Embodiment 3

[0033] Example 3 Preparation of fully substituted thiophene compound 2c

[0034] Thiophene compound 2c was fully substituted by acetylenic compound 1c, and the reaction conditions were as in Example 1. The structure of the product was confirmed to be fully substituted thiophene 2c by NMR and IR, and the yield was 85%.

[0035]

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Abstract

The invention relates to a preparation method of totally-substituted thiophene and belongs to the field of chemical synthesis. The preparation method comprises the following steps: stirring elemental sulfur and a double-molecule alkynyl ketone type compound under the catalysis of an inorganic strong alkali until reaction ends, and separating the obtained mixture to obtain a thiophene product. The method is simple and convenient to operate, easy jn obtaining of raw materials, mild in reaction condition, high in yield, simple and easy in separation of reaction products, low in cost and applicable to industrial production.

Description

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Claims

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Application Information

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Owner GUANGDONG UNIV OF PETROCHEMICAL TECH
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