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Liquid chromatograph device and liquid delivery device

A technology of liquid chromatography and liquid feeding device, which is used in measuring devices, instruments, scientific instruments, etc., can solve problems such as the difference between the time of mixing ratio composition and the actual suction time, and the reduction of the mixing performance of the eluent.

Active Publication Date: 2016-08-24
HITACHI HIGH-TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In this way, in the low-pressure gradient method, the composition of the eluent is changed on the upstream side of the liquid-feeding device, so the mixing performance of the eluent may decrease as the liquid-feeding pressure increases.
[0007] This is because the eluent is not sucked into the cylinder until the pressure in the cylinder is decompressed to atmospheric pressure when the piston in the cylinder, which has finished ejecting the eluent, starts to suck. There is a difference between the time of changing the composition of the mixing ratio and the actual suction time

Method used

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  • Liquid chromatograph device and liquid delivery device
  • Liquid chromatograph device and liquid delivery device
  • Liquid chromatograph device and liquid delivery device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] figure 1 An outline of the configuration of a liquid chromatograph apparatus that performs liquid delivery by a low-pressure gradient method is shown.

[0031] In this device, a plurality of eluents stored in a plurality of containers 1 a to 1 d are selected by a switching device 2 having a plurality of on-off valves, and sucked and ejected by a liquid delivery device 3 . The ejected eluent is sent to the switching device 2 .

[0032] The switching device 2 can change the mixing ratio of the eluent sent from the liquid feeding device 3 and change the composition ratio of the eluent by selectively switching the eluent in the containers 1a to 1d.

[0033] The sample injection unit 4 injects a liquid sample to be analyzed into the eluent channel switched by the switching device 2 .

[0034] The injected liquid sample is separated for each component in the separation column 5 . Due to differences in molecular weight, hydrophobicity, charge, etc., the time for each compon...

Embodiment 2

[0083] Figure 8 represents an example of a liquid delivery device, which is associated with figure 2 The embodiment shown differs in that each cylinder has its own drive and motor, independently driving the pistons. In this example, the piston is driven by converting the rotational motion of the motor into linear motion by a direct drive unit connected to the motor.

[0084] The rotational motion of the electric motors 42, 43 is transmitted to the direct-acting drive parts 38, 39, and the pistons 34, 35 reciprocate by the reciprocating motion of the direct-acting drive parts. As the direct drive unit, for example, a ball screw can be cited.

[0085] The moving direction of each piston is determined according to the rotation direction of the connected motor, and the moving distance of the piston is identified according to the rotation speed of the motor. Especially when a stepping motor is used, the moving distance of the piston can be counted as the number of pulses.

[...

Embodiment 3

[0091] Figure 9 represents an example of a liquid delivery device, which is associated with figure 2 The embodiment shown differs in that the cylinders are connected in parallel.

[0092] exist Figure 9 When applying a low-pressure gradient to the liquid feeding device shown, it is necessary to install the switching device 2 having switching valves 7 a to 7 d upstream of the branch point 45 that supplies the solvent to the first cylinder 47 and the second cylinder 50 .

[0093]In the liquid feeding device in which cylinders are connected in parallel (parallel), each connected cylinder has steps of absorbing, compressing, and ejecting the solvent.

[0094] From the solvent absorption of the first cylinder 47 to the compression process of the absorbed solvent, the second cylinder 50 independently discharges to the downstream system, and performs the compression process from the solvent absorption of the second cylinder 50 to the absorbed solvent. Until the end, the first c...

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PUM

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Abstract

Provided are a low pressure gradient liquid delivery device and liquid chromatography device that are accurate and highly precise regardless of the variety, temperature, mixing ratio or liquid delivery pressure of the eluent. The devices comprise: pump units, which have a cylinder with an eluent intake port and discharge port and a plunger that moves in a reciprocating manner inside the cylinder and which draw in and discharge the eluent; a valve means for switching between multiple kinds of eluents that are drawn up by the pump units using opening and closing actions; a pressure sensor for detecting the pressure of the eluent discharged from the discharge port of the pump units; and a control unit for controlling the opening and closing actions of the valve means. When said multiple eluents are drawn up, the control unit determines the pressure reduction interval from the discharge pressure when the plungers begin the intake action until the eluent starts to be drawn up and, after the pressure reduction interval, the actual intake interval during which the eluent is actually drawn up, and performs control so that the opening and closing actions of the valve means are performed within the determined actual intake interval.

Description

technical field [0001] The invention relates to a liquid chromatograph device and a liquid sending device. Background technique [0002] A liquid chromatograph is a device that adds a sample to be analyzed to a solvent (eluent) sent from a liquid delivery device, separates the components of the sample through a separation column, and detects the components of the sample sent at different times by a detector such as a spectrometer. Composition, to determine the composition of the sample. [0003] As an example of a liquid sending device of a liquid chromatograph, a system in which an eluent is sent by a piston reciprocating in a cylinder is known. [0004] In the liquid delivery of the liquid chromatograph using the above-mentioned device, there is a gradient liquid delivery system that uses a plurality of eluents while changing the composition of the eluent, thereby improving the concentration of the sample to be analyzed. The resolution in the separation column seeks to s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/32G01N30/34
CPCG01N30/24G01N30/34G01N2030/326
Inventor 秋枝大介和田宏之福田真人田上丰明塚田修大
Owner HITACHI HIGH-TECH CORP