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A new drug application of iridoid glycosides

A drug, the only technology, applied in the field of medicine, can solve the problems of drug resistance, undetermined course of treatment, long course of treatment, etc.

Active Publication Date: 2018-03-02
樊向德 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is that the course of treatment is relatively long, and the course of treatment is not particularly determined. Some people need two years, and some may be longer, requiring long-term medication.
Another disadvantage is the problem of drug resistance in the process of long-term medication

Method used

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  • A new drug application of iridoid glycosides
  • A new drug application of iridoid glycosides
  • A new drug application of iridoid glycosides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0307] Take 500g gardenia, chop it, soak it with 4L 30% (V / V) ethanol for 1 hour, reflux extraction for 2 hours, then reflux extraction with 3L ethanol of the same concentration for 1 hour, filter, combine the filtrates, and recover ethanol under reduced pressure (-9Pa , 60°C) to obtain the extract; load the extract on AB-8 macroporous resin, elute with 2 times the column volume of water, load the eluate on ADS-7 macroporous resin, and use 2 times the column volume, The ethanol with a concentration of 30% (V / V) was eluted, and the eluent was decompressed to recover ethanol and then loaded on the ADS-7 macroporous resin. ethanol elution, the eluent is decompressed to recover ethanol, continued to concentrate under reduced pressure, and the concentrated solution is treated with absolute ethanol to obtain the monomer component genipin-1-β-D gentiobioside.

Embodiment 2

[0309] Take 1000g gardenia, chop it, soak it with 8L 70% (V / V) ethanol for 1 hour, reflux extraction for 2 hours, then extract it with 7L ethanol of the same concentration for 1 hour, filter, combine the filtrates, and recover ethanol under reduced pressure (-9Pa, 60°C) to obtain the extract; load the extract on D101 macroporous resin, elute with 3 times the column volume of water, and load the eluate on S-8 macroporous resin, use 3 times the column volume at a concentration of 20 % (V / V) ethanol, the eluent was decompressed to recover ethanol and then loaded on S-8 macroporous resin, and continued to elute with 2 times column volume and 40% (V / V) ethanol , ethanol is recovered from the eluate under reduced pressure, continued to be concentrated under reduced pressure, and the concentrated solution is treated with absolute ethanol to obtain the monomer component genipin-1-β-D gentiobioside.

Embodiment 3

[0311] Take 600g of gardenia, chop it up, immerse and extract with 5.4L of room temperature water for 6 hours, and then immerse and extract with 4.2L of water for 4 hours. During the immersion, you need to stir, filter, and combine the filtrates to obtain an extract. Put the extract in AB- Load the sample on 8 macroporous resin, elute with 2 times column volume of water, load the eluent on S-8 macroporous resin, elute with 2 times column volume and 20% (V / V) ethanol, elute After dehydration and decompression to recover ethanol, load the sample on S-8 macroporous resin, continue to elute with 2 times the column volume and 40% (V / V) ethanol, and decompress the eluent to recover ethanol, continue to decompress Concentrate, and the concentrate is treated with absolute ethanol to obtain the monomer component genipin-1-β-D gentiobioside.

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Abstract

The invention belongs to the field of medicines and particularly relates to a new application of an iridoid glycoside compound, genipin-1-[beta]-D-gentiobioside, and a composition composed by compounding the genipin-1-[beta]-Dgentiobioside with other components as effective components for preparing antiviral drugs, antibacterial drugs, fever alleviating drugs, inflammation resistant drugs and anti-oxidizing drugs. The iridoid glycoside compound and the composition can be used for treating acute respiratory infection, flu, pneumonia, viral hepatitis type B, herpes zoster, herpes viral keratitis, viral myocarditis, Epstein-Barr virus infection, retrovirus infectious diseases and bacterial infectious diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to an iridoid glycoside compound-genipin-1-β-D gentiobioside and a composition formed by compatibility with other ingredients for the preparation of antiviral, antibacterial, Novel uses in thermal, anti-inflammatory, antioxidant medicines. Background technique [0002] Acute respiratory infection is not only a common and frequently-occurring disease in clinical practice, especially in recent years, the emergence of SARS, human avian influenza, H1N1 influenza and H7N9 influenza has put human beings in danger of a pandemic at any time, and existing anti-infective drugs and vaccines cannot effectively deal with the continuous Varying sources of infection. Therefore, finding effective and safe therapeutic drugs is a major problem facing mankind in the 21st century. [0003] Hepatitis B virus is a worldwide epidemic and is a worldwide public health problem. It has the characteristics...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P31/12A61P31/04A61P29/00A61P39/06A61P11/00A61P31/16A61P11/14A61P31/20A61P1/16A61P31/22
CPCA61K31/7048A61K36/744A61K2300/00Y02A50/30
Inventor 樊向德陈鸣珍
Owner 樊向德
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