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Producing method of sodium 4-flurobenzenesulfinate

A technology of sodium fluorobenzene sulfinate and production process, applied in the field of medicine, can solve the problems of complex process, low yield, low purity and the like, and achieve the effect of shortening the process flow

Inactive Publication Date: 2015-04-15
TIANJIN RUIAN MEDICAL TECH DEV
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

[0002] Sodium p-fluorobenzenesulfinate is an important pharmaceutical intermediate, and its purity plays a vital role in the production of subsequent drugs. However, the current production technology of sodium p-fluorobenzenesulfinate still has complex processes and high purity Shortcomings such as low, low output, a kind of production process of sodium p-fluorobenzenesulfinate that can improve the output and purity of sodium p-fluorobenzenesulfinate has not been found yet, and needs to be developed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Step 1, the synthesis of p-fluorobenzenesulfonyl chloride:

[0024] (1) Synthesis:

[0025] Add a certain amount of chlorosulfonic acid to the enamel reaction kettle to lower the temperature of the material in the kettle to 10-20°C, start adding fluorobenzene dropwise, and control the reaction temperature below 25°C with the dropping speed. Keep stirring for 0.5 hours, then suck the generated p-fluorobenzenesulfonyl chloride feed solution into the overhead tank for use, and the molar ratio of fluorobenzene to chlorosulfonic acid is 1:4;

[0026] (2) Hydrolysis:

[0027] Add a certain amount of tap water to the enamel reaction kettle to lower the temperature, then slowly add the p-fluorobenzenesulfonyl chloride generated in step (1) dropwise, control the reaction temperature below 30°C with the dropping speed, and continue stirring for 5 minutes after the dropwise addition is completed;

[0028] (3) Centrifugal separation:

[0029] Slowly put the hydrolyzed p-fluorobe...

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Abstract

The invention provides a producing method of sodium 4-flurobenzenesulfinate. A sodium 4-flurobenzenesulfinate product is prepared by synthesizing 4-Fluorobenzensulfonyl chloride, synthesizing the sodium 4-flurobenzenesulfinate and performing a neutralization reaction and post-treatment processes. The producing method of sodium 4-flurobenzenesulfinate is reduced in technical processes, and can achieve a product yield of 65% and a product purity of 98%.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a production process of sodium p-fluorobenzenesulfinate. Background technique [0002] Sodium p-fluorobenzenesulfinate is an important pharmaceutical intermediate, and its purity plays a vital role in the production of subsequent drugs. However, the current production technology of sodium p-fluorobenzenesulfinate still has complex processes and high purity Shortcomings such as low, yield are low, a kind of sodium p-fluorobenzene sulfinate production process that can improve sodium p-fluorobenzene sulfinate yield and purity has not been found yet, awaits development. Contents of the invention [0003] The invention provides a production process of sodium p-fluorobenzenesulfinate. [0004] In order to realize above-mentioned purpose of the invention, the embodiment that the present invention takes is as follows: [0005] (1) Synthesis of p-fluorobenzenesulfonyl chloride: [0006] (1) ...

Claims

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Application Information

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IPC IPC(8): C07C313/04
Inventor 王旭赵合利王家濬
Owner TIANJIN RUIAN MEDICAL TECH DEV
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