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Immunoregulation peptide, and preparation method and application thereof

An immune regulation and antibacterial peptide technology, applied in the fields of medicine and bioengineering, can solve problems such as lack of research, and achieve high safety and the effect of strongly promoting the proliferation of T lymphocytes

Inactive Publication Date: 2015-04-22
NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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  • Abstract
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AI Technical Summary

Problems solved by technology

There is no report on further research on these fragments and their functions in the prior art. Therefore, we screened some polypeptides for in-depth research

Method used

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  • Immunoregulation peptide, and preparation method and application thereof
  • Immunoregulation peptide, and preparation method and application thereof
  • Immunoregulation peptide, and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0039] 1. The polypeptide has the following sequence characteristics:

[0040] Amino acid sequence: GRVMPVLKSPTIPFFDPQIPK (SEQ ID NO: 1)

[0041] Nucleotide sequence:

[0042] GGCAGAGTGATGCCTGTCCTTAAATCTCCAACGATACCCTTTTTTGACCCTCAAATCCCAAAA (SEQ ID NO: 2)

[0043] It has isoelectric point (pI): 9.99, molecular weight (Mw): 2367.88.

[0044] 2. After chemically synthesizing the peptide, the MTT experiment found that the peptide has a strong effect of promoting T lymphocyte proliferation (see figure 1 ).

[0045] use T lymphocyte separation reagent (ONE LAMBDA, US) was used to separate human blood T lymphocytes, and RPMI 1640 (containing 10% FCS, 100U / ml penicillin / streptomycin) culture medium was used to adjust the cell concentration to about 4×10 6 pieces / ml. The effect of the chemically synthesized immunomodulatory peptide (chemically synthesized peptide) on the proliferation of T lymphocytes was detected by the traditional MTT method. Add 50 μl of cells and 150 μl of ...

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PUM

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Abstract

The invention belongs to the fields of medicine and bioengineering, and discloses an immunoregulation peptide, and a preparation method and application thereof. The amino acid sequence of the immunoregulation is disclosed as SEQ ID NO:1. The immunoregulation peptide has high T lymphopoiesis promoting function, and can be used for preparing T lymphopoiesis promoting drugs.

Description

technical field [0001] The invention belongs to the fields of medicine and bioengineering, and relates to an immunomodulatory peptide and its preparation method and application. Background technique [0002] Modern nutritional studies have found that most of the protein ingested by humans is digested and absorbed in the form of small peptides after the action of enzymes in the digestive tract, and the proportion absorbed in the form of free amino acids is very small. Further experiments have revealed that the absorption of small peptides is higher than that of free amino acids. Absorbs more quickly. Another new understanding of the nutritional role of peptides is that some bioactive peptides with special physiological regulation functions can be produced during the enzymatic hydrolysis of proteins. These bioactive peptides play an important role in regulating gastrointestinal motility, regulating the immune system, antihypertensive, antibacterial, antithrombotic, antiviral,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47C12N15/12C12N15/11C12N15/70A61K38/17A61P37/04A23C9/152
CPCC07K14/4732A23C9/1526A61K38/00
Inventor 郭锡熔季晨博崔县伟尤梁惠史春梅
Owner NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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