Full-automatic immuno-fluorescence quantitative analysis device and implementation method

A quantitative analysis and fluorescence immunoassay technology, which is applied in the field of quantitative fluorescence immunoassay detection, can solve the problems of increasing manual intervention test errors, inaccurate sampling accuracy, and delaying disease diagnosis, so as to realize automated testing, reduce human errors, and improve The effect of precision

Active Publication Date: 2015-04-22
GETEIN BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] When performing fluorescent immunoassay quantitative detection, most of the diagnostic instruments currently on the market are semi-automatic detection instruments. For example, the existing fluorescent immunochromatography analyzer GP1100 of Nanjing Jidan Biotechnology Co., Ltd. is a semi-automatic detection instrument. Its machine structure is only It includes an optical path system and electronic display system for quantitative inspection. The process of adding samples and chromatography is done manually outside the machine; in use, first of all, because the semi-automatic instrument adds samples outdoors, it requires high temperature for some The product inspection is very unfavorable; secondly, because of the need for manual sampling and sample addition steps, and then quantitative analysis by instruments, the test error caused by manual intervention is increased, the development time of immunochromatography, and the accuracy of sample addition are not good. Accurate, slow test speed, manual sample addition is easy to cause biological contamination; finally, most of the existing small detection instruments can only load one sample at a time, and then add another sample to it after the test is completed
This has caused the following disadvantages: there must be a special manual on duty, repeated operations to load samples, manual intervention to cause biological contamination, and at the same time, the inspectors cannot leave to perform other inspections; in addition, one at a time is inspected, which is inefficient and delays the diagnosis of the disease; Outdoor sampling is not suitable for product testing with high temperature requirements

Method used

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  • Full-automatic immuno-fluorescence quantitative analysis device and implementation method
  • Full-automatic immuno-fluorescence quantitative analysis device and implementation method
  • Full-automatic immuno-fluorescence quantitative analysis device and implementation method

Examples

Experimental program
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Effect test

Embodiment 1

[0050] Such as figure 2 , 3 , 4, a fully automatic fluorescent immunoassay analysis device, including a support base plate 1 and a control system, and also includes a reagent strip storage and automatic loading module 3, a reaction disk module 4, a detection module 5, and a sample array arranged in sequence on the base plate Module 6, sampling module 7 and washing module 8; reagent strip storage and automatic loading device 3 provides reagent strips for the reaction disk module 4, and the sample loading module 7 adds the sample in the sample module 6 to the reagent strip of the reaction disk module 4 Carry out the reaction, and enter the detection module 5 after completing the reaction to complete the detection.

[0051] Such as figure 2 , 4 As shown, the sample adding module 7 includes an XYZ moving mechanical arm and a disposable suction head picker 12; the X arm 9 is arranged horizontally and can be located at the top of the circuit box 2, and the Y arm 10 is located a...

Embodiment 2

[0062] A fully automatic fluorescent immunoassay quantitative analysis device, the specific structure of the reagent strip storage and automatic loading module 3 and the supporting reaction disk module 4 is as follows, and the other modules are similar in structure to the embodiment 1.

[0063] Such as Figure 6 As shown, the reaction disk module 4 is a disk-shaped device, and a plurality of reagent strip slots 26 are fixed on the edge of the disk, and the slot openings correspond to the positions of the reagent strip outlets 27, as shown in FIG. Figure 7 As shown, there is a gap 28 in the middle of the lower bottom surface of the reagent strip slot 26, and the gap 28 allows the elastic hanging rod 38 to send the reagent strip into the reagent strip slot 26; the lower part of the reaction tray module 4 passes through the base plate and the first motor at the bottom of the base plate 29, the first motor 29 is connected to the control system, and the control system drives the f...

Embodiment 3

[0076] A fully automatic fluorescent immunoassay quantitative analysis device, the detection module 5 is provided with elastic hooks, and the structure of other modules is similar to that of embodiment 2.

[0077] After the detection module 5 completes the detection of the reagent strip, the elastic hook under the detection module 5 pushes the reagent strip out of the reaction tray and enters under the detection device. After the detection of the next reagent strip is completed, the previous reagent strip is pushed out of the device of this embodiment by the next reagent strip, and the next reagent strip remains under the detection device.

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Abstract

The invention discloses a full-automatic immuno-fluorescence quantitative analysis device and an implementation method, belonging to the field of quantitative immuno-fluorescence analysis and detection. The full-automatic immuno-fluorescence quantitative analysis device comprises a supporting bottom plate, a reagentstrip storage and automatic loading module, a reactiondisc module, a detection module, a sample module, a sample adding module, a washing module and a control system, wherein the reagentstrip storage and automatic loading module, the reactiondisc module, the detection module, the sample module, the sample adding module and the washing module are arranged on the supporting bottom plate in sequence; the reagentstrip storage and automatic loading module provides a reagent strip for the reactiondisc module; the sample adding module is used for adding samples in the sample module into the reactiondisc module to carry out reaction, and after reaction is finished, the samples enter the detection module to be detected. The full-automatic immuno-fluorescence quantitative analysis device and the implementation method disclosed by the invention have the advantages that the difficulty that automation is hard to implement for an in-vitro diagnosis product is solved, the artificial error is reduced, the testing accuracy is improved and the detection efficiency is improved.

Description

technical field [0001] The invention belongs to the field of quantitative fluorescence immunoassay detection, in particular to a fully automatic fluorescence immunoassay quantitative analysis method and device. Background technique [0002] POCT, point-of-care testing is a subdivision of in vitro diagnostic devices (IVD), that is, on-site sampling and immediate analysis, eliminating the complicated procedures of specimen testing in the laboratory and quickly obtaining test results. [0003] When performing fluorescent immunoassay quantitative detection, most of the diagnostic instruments currently on the market are semi-automatic detection instruments. For example, the existing fluorescent immunochromatography analyzer GP1100 of Nanjing Jidan Biotechnology Co., Ltd. is a semi-automatic detection instrument. Its machine structure is only It includes an optical path system and electronic display system for quantitative inspection. The process of adding samples and chromatograp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/02
CPCG01N2035/00326G01N2035/0465G01N35/00029G01N35/025G01N35/04G01N2035/00108G01N2035/0444G01N2035/0498G01N2035/103G01N33/54366G01N35/00871G01N35/1011G01N2035/0484
Inventor 苏恩本陈维森尹凌志王林李靖金晶
Owner GETEIN BIOTECH
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