Preparation method of imidocarb dipropionate sterile APIs (active pharmaceutical ingredients)
A technology of imidazolium dipropionate and imidazolidinium phenylurea is applied in the field of preparation of aseptic raw materials of imidazolium dipropionate, can solve problems such as difficulty in production, achieves low cost, simple and convenient operation, and is suitable for large-scale industrialization production effect
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Embodiment 1
[0017] A kind of preparation method of imidazolone dipropionate aseptic crude drug, the steps are as follows:
[0018] 1) Add 34.8kg of imidazolium to 104.4kg of purified water, mix well and stir to form a suspension; heat the suspension to 30°C, control the temperature to maintain 30°C, add 14.8kg of propionic acid dropwise, and stir to react (reaction solution dissolved) to obtain the initial drug solution.
[0019] 2) Pass the initial liquid medicine through the diaphragm pump and the third-stage filter respectively, and pressurize the pump to control the delivery speed of the liquid to 1.0kg / min; in the third-stage filter, the pore size of the first-stage filter element is 0.5um , the pressure is 4bar; the pore diameter of the second stage filter element is 0.2um, the pressure is 4bar, the pore diameter of the third stage filter element is 0.2um, and the pressure is 1.5bar; the sterile medicinal solution is obtained after filtration.
[0020] 3) Spray and dry the sterile ...
Embodiment 2
[0022] A preparation method of imidazuron dipropionate aseptic bulk drug, the steps are as follows:
[0023] 1) Add 34.8kg of imidazolium to 208.8kg of purified water, mix well and stir to form a suspension; heat the suspension to 35°C, control the temperature to maintain 35°C, add 17.0kg of propionic acid dropwise, and stir to react (reaction solution dissolved) to obtain the initial drug solution.
[0024] 2) Pass the initial liquid medicine through the diaphragm pump and the third-stage filter respectively, and pressurize the delivery speed of the liquid to be 1.5kg / min when passing through the diaphragm pump; the pore size of the first-stage filter element in the three-stage filter filtration is 0.5 microns , the pressure is 5.1bar; the pore size of the second-stage filter element is 0.2 micron, the pressure is 5.1bar, the pore size of the third-stage filter element is 0.2 micron, and the pressure is 1.8bar; the sterile medicinal solution is obtained after filtration.
[...
Embodiment 3
[0027] A preparation method of imidazuron dipropionate aseptic bulk drug, the steps are as follows:
[0028] 1) Add 34.8kg of imidazolium to 348kg of purified water, mix well and stir to form a suspension; heat the suspension to 40°C, control the temperature to maintain 40°C, add 14.8kg of propionic acid dropwise, and stir to react (the reaction solution dissolves ) to get the initial drug solution.
[0029] 2) Pass the initial liquid medicine through the diaphragm pump and the third-stage filter respectively, and pressurize the pump to control the delivery speed of the liquid to 2.0kg / min; in the third-stage filter, the pore size of the first-stage filter element is 0.5um , the pressure is 6bar; the pore diameter of the second-stage filter element is 0.2um, the pressure is 6bar, the pore diameter of the third-stage filter element is 0.2um, and the pressure is 2bar; the sterile medicinal solution is obtained after filtration.
[0030] 3) Spray and dry the sterile medicinal li...
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