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Micro tangential flow filtration simulation device

A tangential flow filtration, simulation device technology, applied in enzymology/microbiology devices, biochemical cleaning devices, methods of supporting/immobilizing microorganisms, etc., can solve the problem of poor sealing performance and can not completely accurately simulate shear force distribution Status and other issues to achieve the effect of saving development costs and shortening the development cycle

Inactive Publication Date: 2015-06-03
EAST CHINA UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a cell for the technical defects of the existing miniature tangential flow filtration simulation device for protein separation test, which has poor sealing performance and cannot completely and accurately simulate the shear force distribution of ordinary tangential flow filtration. , cell sub-particles and protein separation formula test with a miniature tangential flow filtration simulation device, which reduces the cost of the entire device and improves the authenticity and accuracy of laboratory simulations

Method used

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  • Micro tangential flow filtration simulation device
  • Micro tangential flow filtration simulation device
  • Micro tangential flow filtration simulation device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1, as attached figure 2 As shown, the raw material tank 1 includes a tank body 101, the tank body 101 is mounted on a tank base 102, the mouth of the tank body 101 is sealed with a tank cover 103, and the upper part of the tank body 101 is provided with a liquid inlet pipe 104 and a liner pipe. 105 is in communication with the outside, and the lower part of the tank body 101 is provided with a liquid outlet pipe 106 to communicate with the outside. The liquid inlet pipe 104 is connected to the back pressure valve 4 and the liquid outlet pipe 106 is connected to the peristaltic pump 2.

[0027] As attached image 3 , 4 As shown in and 5, the filter device 3 includes an upper circulation box 301 and a lower circulation box 302. The upper circulation box 301 and the lower circulation box 302 are attached and fixed together, and the upper circulation box 301 and the lower circulation box 302 A filter membrane 303 is arranged between the bonding surfaces of the box body...

Embodiment 2

[0035] The flow channel shapes of the lower flow channel 302a and the upper flow channel groove 301a are rectangular.

Embodiment 3

[0037] The flow channel shapes of the lower flow channel 302a and the upper flow channel groove 301a are annular.

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Abstract

A micro tangential flow filtration simulation device is characterized by comprising a raw material tank (1), wherein a raw material liquid in the raw material tank (1) is pumped into a filter (3) by a peristaltic pump (2) on an output pipeline of the raw material tank (1), an output end of the filter (3) is connected with a back-pressure valve (4), an output end of the back-pressure valve (4) is connected back to the raw material tank (1), a first pressure sensor (5) is mounted on a connecting pipeline of the peristaltic pump (2) and the filter (3), and a second sensor (6) is mounted on a connecting pipeline of the filter (3) and the back-pressure valve (4). According to the micro tangential flow filtration simulation device, the micro tangential flow filter is used and has the sealing strength of at least two atmospheres, the liquid flows along a runner in the filter and does not leak in the runner, and the micro raw material tank is combined, so that the simulation device is miniaturized, rapid development of a low-cost, high-speed and high-flux downstream process for high-value biological agents can be realized, the development cost is saved, and the development cycle is shortened.

Description

Technical field [0001] The invention belongs to the technical field of biopharmaceutical experimental equipment, and specifically relates to a miniature tangential flow filtration simulation device in the biopharmaceutical industry, which reduces the volume of the simulation device, improves the simulation test accuracy, and makes high-throughput large-batch experiments become may. Background technique [0002] With the development of science and technology, medical proteins represented by monoclonal antibodies, as the main products of the biopharmaceutical industry, occupy a significant share of the pharmaceutical market. In the entire production process, the cost of the downstream separation and purification process accounts for 50%-80% of the total cost. Among them, the tangential flow membrane separation technology has become the main factor in cell-crude protein separation, protein-protein separation, and protein solution replacement. Separation means. [0003] In recent yea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34C12M1/12C07K1/34
Inventor 关岳隋朔王世立王华
Owner EAST CHINA UNIV OF SCI & TECH