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A kind of preparation method and product of oxidized resveratrol microcapsule

A technology for oxidizing resveratrol and microcapsules, which is applied in the direction of microcapsule preparations and microsphere preparations, can solve the problems of complex modification methods, uneven dispersion, and difficult operation, and achieve improved embedding rate, low content, and reduced The effect of production costs

Active Publication Date: 2017-03-01
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Application number 201110142129.2 "Preparation method of water-soluble stilbene compound prodrug" discloses a preparation method of water-soluble stilbene compound prodrug, using PEG (or mPEG)-succinyl (or acetyl)- Amino acids are used as modifiers to modify stilbene compounds such as stilbene modder, oxidized resveratrol, pterostilbene, picatanol, and resveratrol to prepare their prodrugs. The modified prodrugs improve their Water solubility and stability improve biological activity and achieve the purpose of slow and controlled release, but this modification method is complicated and difficult to operate
[0008] This patent uses β-cyclodextrin, chitosan, gum arabic, and maltodextrin as wall materials, and a microencapsulation process prepares a kind of high embedding rate, high sample loading capacity, good water solubility, good stability, and is not easy Discoloration and other advantages solve the problems of low water solubility, uneven dispersion and easy discoloration

Method used

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  • A kind of preparation method and product of oxidized resveratrol microcapsule
  • A kind of preparation method and product of oxidized resveratrol microcapsule

Examples

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Effect test

Embodiment 1

[0031] A preparation of oxidized resveratrol microcapsules, comprising the following steps:

[0032] (1) Ingredients. At room temperature, add four wall materials of maltodextrin, chitosan, gum arabic and β-cyclodextrin in a weight ratio of 2:1:3:1 to the batching tank;

[0033] (2) Dissolving and sterilizing. At room temperature, add water 1.5 times the weight of the wall material, make the ingredients in step (1) into an aqueous solution of the wall material with a solid content of 40%, sterilize it in a constant temperature water bath at 85°C for 30 minutes, and homogenize twice at 10MPa. Homogenize once at 50 MPa to obtain a uniform and stable emulsion;

[0034] (3) Dissolving the core material. Add oxidized resveratrol to 50 ml ethyl acetate and petroleum ether mixed solution (ethyl acetate: petroleum ether volume ratio is 1:1), and heat to dissolve;

[0035] (4) Pretreatment. After cooling the wall material aqueous solution obtained in step (2) to 50°C, add the oxid...

Embodiment 2

[0040] A preparation of oxidized resveratrol microcapsules, comprising the following steps:

[0041] (1) Ingredients. At room temperature, add maltodextrin, chitosan, gum arabic and β-cyclodextrin four kinds of wall materials with a weight ratio of 1:2:5:2 to the batching tank;

[0042](2) Dissolving and sterilizing. At room temperature, add water 1.5 times the weight of the wall material, make the ingredients in step (1) into an aqueous solution of the wall material with a solid content of 40%, sterilize it in a constant temperature water bath at 85°C for 30 minutes, and homogenize once at 30 MPa , and then homogenize once at 40 MPa to obtain a uniform and stable emulsion;

[0043] (3) Dissolving the core material. Add oxidized resveratrol to 80 ml ethyl acetate and petroleum ether mixed solution (ethyl acetate: petroleum ether volume ratio is 2:1), and heat to dissolve;

[0044] (4) Pretreatment. After cooling the wall material aqueous solution obtained in step (2) to 5...

Embodiment 3

[0049] A preparation of oxidized resveratrol microcapsules, comprising the following steps:

[0050] (1) Ingredients. At room temperature, add maltodextrin, modified starch and sucrose with a weight ratio of 2:2:2:1 to the batching tank;

[0051] (2) Dissolving and sterilizing. At room temperature, add water 1.5 times the weight of the wall material, make the ingredients in step (1) into an aqueous solution of wall material with a solid content of 40%, sterilize with constant temperature water bath shaking at 80°C for 30 min, and homogenize twice at 25 MPa , and then homogenized twice at 40 MPa to obtain a uniform and stable emulsion;

[0052] (3) Dissolving the core material. Add oxidized resveratrol to 100 ml ethyl acetate and petroleum ether mixed solution (ethyl acetate: petroleum ether volume is 4:1), and heat to dissolve;

[0053] (4) Pretreatment. After cooling the wall material aqueous solution obtained in step (2) to 50°C, add the oxidized resveratrol solution in...

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Abstract

The invention discloses a preparation method of oxyresveratrol microcapsules and products thereof. The method comprises the following steps: (1) selecting beta-cyclodextrin, chitosan, Arabic gum, and maltodextrin as split timbers, adding water for preparing a split timber aqueous solution, heating the split timber aqueous solution so as to completely dissolve the split timbers, and carrying out sterilization and homogenization on the obtained object so as to obtain an emulsion; (2) adding oxyresveratrol into a small amount of ethyl acetate and petroleum ether mixed solvent, heating for dissolving so as to obtain an oxyresveratrol solution; (3) cooling the emulsion obtained in the step (1) to 45-50 DEG C, stirring the emulsion to completely uniformly mix the emulsion, so that an emulsion with a solid content of 25-50% is obtained, and adding the oxyresveratrol solution to re-homogenize, so that an oxyresveratrol and split timber emulsion is obtained; and (4) carrying out spray drying on the oxyresveratrol and split timber emulsion obtained in the step (3), so that oxyresveratrol microcapsule powder is obtained. The method disclosed by the invention has the advantages of high embedding rate, high sample loading quantity, good water solubility, high stability and not easiness for discoloration, and the like.

Description

technical field [0001] The invention relates to the technical field of processing polyhydroxy trans-stilbene natural products, in particular to a preparation method of oxidized resveratrol microcapsules and a product thereof. Background technique [0002] Oxyresveratrol (Oxyresveratrol) is the 2'-hydroxylation derivative of polyhydroxy trans-stilbene natural product resveratrol (Resveratrol) that has attracted much attention in recent years. Oxidized resveratrol is colorless or light yellow rod-like crystals, needle-like crystals. It is unstable in alkaline environment or high-temperature water environment. Because it has multiple phenolic hydroxyl groups, the ferric chloride reagent is dirty green, and it has anti-oxidation effect and inhibits protein kinase and other biological activities. [0003] The structural formula of oxidized resveratrol is as follows: [0004] [0005] oxyresveratrol or trans-2,3',4,5'-Tetrahydroxystilbene [0006] Studies in recent years hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02
Inventor 曹庸刘果杜洁刘飞李俊徐鸿戴伟杰
Owner SOUTH CHINA AGRI UNIV
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