Marker for postpartum eclampsia diagnosis and detection reagent thereof

A postpartum eclampsia and marker technology, applied in the field of markers and its detection reagents, can solve the problems of differences in clinical manifestations of patients, limited understanding of disease pathogenesis and basic understanding of occurrence and development, and achieve high specificity and strong sensitivity

Active Publication Date: 2015-06-17
浙江佳米生物医药科技有限公司
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  • Application Information

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Problems solved by technology

On the one hand, this is due to the obvious complexity and heterogeneity of these diseases. The severity of the disease, the course of the disease, the early or late onset, and the genetic background of the patient will lead to huge differences in clinical manifestations; another important factor is the understanding of the disease. The understanding of the pathogenesis and basis of development is still very limited

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  • Marker for postpartum eclampsia diagnosis and detection reagent thereof
  • Marker for postpartum eclampsia diagnosis and detection reagent thereof
  • Marker for postpartum eclampsia diagnosis and detection reagent thereof

Examples

Experimental program
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Embodiment 1

[0029] Example 1: Discovery and verification of clinical diagnostic markers for postpartum eclampsia

[0030] 1.1 Selection and grouping of research objects

[0031] The research objects of this example were all 40 women who underwent cesarean section in the Obstetrics and Gynecology Department of Qilu Hospital of Shandong University in Jinan City between January 2014 and January 2015. Including 20 patients with postpartum eclampsia (SPE group), as the postpartum eclampsia group, the average age of this group is 29.40±1.111, and the average gestational age is 36.78±0.625. 20 normal healthy pregnant women were taken as the normal pregnancy group (NP group). The average age of this group was 28.73±0.639, and the average gestational week was 39.10±0.233.

[0032] 1.2 Collection and processing of decidua tissue samples

[0033] 1.2.1 Tissue collection: After the placenta is delivered by cesarean section, use sterile gauze to wipe the uterine wall where the placenta is attached, ...

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Abstract

The invention discloses a marker for postpartum eclampsia diagnosis. The marker is one of WNT4 protein and WNT5A protein or a combination thereof. The invention also discloses a reagent for clinical diagnosis of postpartum eclampsia, wherein the reagent comprises one or both of a WNT4 antibody and a WNT5A antibody, an HRP rabbit anti-goat antibody and a beta-actin antibody. The detection reagent disclosed by the invention has the advantages of high sensitivity and high specificity and can be widely applied to preliminary investigation and health screening of postpartum eclampsia so as to provide reliable data to clinical diagnosis.

Description

technical field [0001] The invention relates to a marker and a detection reagent for postpartum eclampsia diagnosis. Background technique [0002] Eclampsia refers to a disease in which a pregnant woman suffers from dizziness, headache, sudden loss of consciousness, binocular upsight, tetany, general rigidity, waking up in a short while, relapse after waking up, or even unconsciousness in the third trimester of pregnancy or during labor or after a new childbirth. Known as "eclampsia", also known as "pregnancy epilepsy". Preeclampsia in pregnancy develops from an exacerbation of the signs and symptoms of preeclampsia. Eclampsia can occur during pregnancy, childbirth or within 24 hours after delivery. It is called prenatal eclampsia, intrapartum eclampsia and postpartum eclampsia respectively. It is one of the four major causes of death in obstetrics. Once it occurs, maternal and child complications and mortality will increase significantly, so special attention should be pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/368
Inventor 闫星宇
Owner 浙江佳米生物医药科技有限公司
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