Intestinal adhesion prevention membrane solution as well as preparation method and application thereof

A technology of intestinal adhesion and membrane fluid, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, cyclic peptide components, etc., can solve the problems of incomplete prevention of peritoneal adhesions, poor anti-adhesion effects, inconvenient use, etc., and achieve inhibition The effect of growth, prevention of adhesion, and ease of use

Active Publication Date: 2015-08-12
南通大禹生物技术有限公司
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  • Abstract
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Problems solved by technology

[0003] At present, the medical devices for preventing peritoneal adhesions include non-absorbable spacers, absorbable spacers, viscous solutions, etc. The spacers can play a better anti-adhes

Method used

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  • Intestinal adhesion prevention membrane solution as well as preparation method and application thereof
  • Intestinal adhesion prevention membrane solution as well as preparation method and application thereof
  • Intestinal adhesion prevention membrane solution as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Preparation method: Under sterile conditions, take 2g of carboxymethyl chitosan and dissolve it in 100ml of normal saline, in a magnetic stirrer, under stirring conditions, gradually add 180mg of cyclosporine A, after continuous stirring for 10min, a solution A is formed ;

[0025] Take 2.5gCaCl 2 Dissolve in 100ml of normal saline to form solution B;

[0026] Film-forming experiment: Add solution B to solution A gradually. As the volume of added solution B increases, a thin film can be gradually formed (when the volume ratio of solution A to solution B reaches 25:8), until the thickness increases (solution A and solution B When the volume ratio of B reaches 25:10, the film has a certain thickness), when the volume ratio of solution A to solution B is 25:20, the weight of the film no longer increases (such as figure 1 shown), the formed film is as figure 2 As shown, at this time, when solution A and solution B reach the completion of the reaction, the effect of film...

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Abstract

The invention discloses an intestinal adhesion prevention membrane solution as well as a preparation method and application thereof. The membrane solution disclosed by the invention comprises a solution A and a solution B, wherein the solution A refers to a normal saline solution dissolved with carboxymethyl chitosan and ciclosporin A; the concentration of the carboxymethyl chitosan in the solution A is 10-40mg/ml; the concentration of the ciclosporin A is 1.0-1.8mg/ml; the solution B refers to a CaCl2 normal saline solution; the concentration of CaCl2 is 2.5mg/ml; and the volume ratio of the solution A to the solution B is (25:8)-(25:40). The membrane solution disclosed by the invention can effectively prevent postoperative intestinal adhesion and is convenient to use.

Description

technical field [0001] The invention specifically relates to a membrane fluid used for preventing peritoneal adhesion after abdominal operation. Background technique [0002] Adhesion is one of the common complications after abdominal surgery. It manifests as abnormal fibrotic adhesion bands between the originally separated organs or organs and the abdominal wall, which can easily lead to inflammation, pain, intestinal obstruction and even female infertility. The incidence of peritoneal adhesions after laparotomy is about 68% to 100%. The effector cells of adhesion and scar are mainly fibroblasts, and the proliferation of this cell plays an important role in the formation of adhesion tissue. [0003] At present, the medical devices for preventing peritoneal adhesions include non-absorbable spacers, absorbable spacers, viscous solutions, etc. The spacers can play a better anti-adhesion effect, but they are inconvenient to use. The solution is convenient to use, but the ant...

Claims

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Application Information

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IPC IPC(8): A61K38/13A61K9/70A61P41/00A61K31/722A61K33/14
Inventor 何红李晓东夏栋林陈超王雨飞陈燕培沈铃玲顾海鹰
Owner 南通大禹生物技术有限公司
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