Photocuring anti-adhesion gel and preparation method thereof
An anti-adhesion and light-curing technology, applied in medical science, surgery, etc., can solve the problem of limited anti-adhesion effect of chronic inflammation and achieve the effect of avoiding adhesion
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Embodiment 1
[0077] This embodiment provides an anti-adhesion gel, which is composed of 11.4% recombinant collagen, 54% vinyl modified recombinant collagen, 34.5% graft particles and 0.1% photoinitiator LAP. Made by curing.
[0078] The vinylation-modified recombinant collagen is specifically modified by vinylation of the recombinant collagen through a modifier, methacrylic anhydride;
[0079] The above-mentioned grafted particles are vinylation-modified recombinant collagen particles of grafted MPC;
[0080] The above-mentioned anti-adhesion gel takes the grafted particles as the inner core, and the biomacromolecules and the vinylation-modified recombinant collagen are coated on the surface of the grafted particles;
[0081] The preparation method of above-mentioned anti-adhesion gel comprises the following steps:
[0082] Step S1, dissolving the recombinant collagen in a phosphate buffer with a pH of 7.4 to prepare a recombinant collagen solution with a concentration of 15 mg / mL; addin...
Embodiment 2
[0090] This embodiment provides an anti-adhesion gel, which is composed of 5% recombinant collagen, 48.7% vinyl modified recombinant collagen, 45.5% graft particles and 0.8% ultraviolet photoinitiator I2959. After homogenization, the wavelength is 365 produced by curing under UV light.
[0091] The vinylation-modified recombinant collagen is specifically modified by vinylation of the recombinant collagen through a modifier, methacrylic anhydride;
[0092] The above-mentioned grafted particles are vinylation-modified recombinant collagen particles of grafted MPC;
[0093] The above-mentioned anti-adhesion gel takes the grafted particles as the inner core, and the biomacromolecules and the vinylation-modified recombinant collagen are coated on the surface of the grafted particles;
[0094] The preparation method of above-mentioned anti-adhesion gel comprises the following steps:
[0095] Step S1, dissolving the reconstituted collagen in a phosphate buffer with a pH of 7.0 to pre...
Embodiment 3
[0103] This example provides an anti-adhesion gel, which comprises 2% hyaluronic acid, 37.5% vinyl modified recombinant collagen, 60% graft particles, and 0.5% blue light initiator LAP after homogenization and curing under light. .
[0104] The vinylation-modified recombinant collagen is specifically modified by vinylation of the recombinant collagen through a modifier, methacrylic anhydride;
[0105] The above-mentioned grafted particles are vinylation-modified recombinant collagen particles of grafted MPC;
[0106] The above-mentioned anti-adhesion gel takes the grafted particles as the inner core, and the biomacromolecules and the vinylation-modified recombinant collagen are coated on the surfaces of the grafted particles;
[0107] The preparation method of above-mentioned anti-adhesion gel comprises the following steps:
[0108] Step S1, dissolving the recombinant collagen in a phosphate buffer of pH 7.8 to prepare a recombinant collagen solution with a concentration of ...
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