Photocuring anti-adhesion gel and preparation method thereof

An anti-adhesion and light-curing technology, applied in medical science, surgery, etc., can solve the problem of limited anti-adhesion effect of chronic inflammation and achieve the effect of avoiding adhesion

Active Publication Date: 2022-07-26
西安臻研生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above-mentioned patent discloses a light-cured anti-adhesion gel made of modified gelatin or collagen, but the hydrogel prepared by the above-mentioned patent method does not contain anti-adhesion components, and degrades too quickly in the body, inflammatory factors, cells, etc. Adhesion, especially for postoperative chronic inflammation, the anti-adhesion effect is limited

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  • Photocuring anti-adhesion gel and preparation method thereof
  • Photocuring anti-adhesion gel and preparation method thereof

Examples

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Embodiment 1

[0077] This embodiment provides an anti-adhesion gel, which is composed of 11.4% recombinant collagen, 54% vinyl modified recombinant collagen, 34.5% graft particles and 0.1% photoinitiator LAP. Made by curing.

[0078] The vinylation-modified recombinant collagen is specifically modified by vinylation of the recombinant collagen through a modifier, methacrylic anhydride;

[0079] The above-mentioned grafted particles are vinylation-modified recombinant collagen particles of grafted MPC;

[0080] The above-mentioned anti-adhesion gel takes the grafted particles as the inner core, and the biomacromolecules and the vinylation-modified recombinant collagen are coated on the surface of the grafted particles;

[0081] The preparation method of above-mentioned anti-adhesion gel comprises the following steps:

[0082] Step S1, dissolving the recombinant collagen in a phosphate buffer with a pH of 7.4 to prepare a recombinant collagen solution with a concentration of 15 mg / mL; addin...

Embodiment 2

[0090] This embodiment provides an anti-adhesion gel, which is composed of 5% recombinant collagen, 48.7% vinyl modified recombinant collagen, 45.5% graft particles and 0.8% ultraviolet photoinitiator I2959. After homogenization, the wavelength is 365 produced by curing under UV light.

[0091] The vinylation-modified recombinant collagen is specifically modified by vinylation of the recombinant collagen through a modifier, methacrylic anhydride;

[0092] The above-mentioned grafted particles are vinylation-modified recombinant collagen particles of grafted MPC;

[0093] The above-mentioned anti-adhesion gel takes the grafted particles as the inner core, and the biomacromolecules and the vinylation-modified recombinant collagen are coated on the surface of the grafted particles;

[0094] The preparation method of above-mentioned anti-adhesion gel comprises the following steps:

[0095] Step S1, dissolving the reconstituted collagen in a phosphate buffer with a pH of 7.0 to pre...

Embodiment 3

[0103] This example provides an anti-adhesion gel, which comprises 2% hyaluronic acid, 37.5% vinyl modified recombinant collagen, 60% graft particles, and 0.5% blue light initiator LAP after homogenization and curing under light. .

[0104] The vinylation-modified recombinant collagen is specifically modified by vinylation of the recombinant collagen through a modifier, methacrylic anhydride;

[0105] The above-mentioned grafted particles are vinylation-modified recombinant collagen particles of grafted MPC;

[0106] The above-mentioned anti-adhesion gel takes the grafted particles as the inner core, and the biomacromolecules and the vinylation-modified recombinant collagen are coated on the surfaces of the grafted particles;

[0107] The preparation method of above-mentioned anti-adhesion gel comprises the following steps:

[0108] Step S1, dissolving the recombinant collagen in a phosphate buffer of pH 7.8 to prepare a recombinant collagen solution with a concentration of ...

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Abstract

The invention discloses a photocuring anti-adhesion gel and a preparation method thereof, and relates to the technical field of biomedical materials. The photocuring anti-adhesion gel is prepared by homogenizing biomacromolecules, vinylation modified recombinant collagen, grafted particles and a photoinitiator and then curing under illumination, the photocuring anti-adhesion gel takes a grafted particle as an inner core, and the biomacromolecule and the vinylation modified recombinant collagen are coated on the surface of the grafted particle; the grafted particles are vinylation modified recombinant collagen particles grafted with MPC (Methoxy Polycarbonate). The anti-adhesion gel provided by the invention not only can achieve the purpose of physical isolation in a short time, but also can achieve an anti-adhesion effect for a long time in a chronic inflammation period.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a light-cured anti-adhesion gel and a preparation method thereof. Background technique [0002] Adhesion is an abnormal structure formed by the combination of connective tissue fibrous bands and adjacent tissues or organs. It is the most common adverse reaction after surgery. It often occurs after abdominal cavity, gynecology, orthopedics, cardiothoracic surgery and other operations, which not only increases the risk of reoperation. It is difficult and can lead to serious complications such as chronic pain, bowel obstruction, infertility, etc. Therefore, preventing postoperative adhesions has become an urgent clinical problem. [0003] In terms of anti-adhesion, domestic and foreign related technicians have researched and developed a variety of technologies, among which, using biodegradable anti-adhesion materials as spacers is the main method at present. There are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/16
CPCA61L31/044A61L31/042A61L31/16A61L31/14A61L2300/424A61L2300/622A61L2300/41
Inventor 宗奕珊仵西凤杨莎莎田智泉
Owner 西安臻研生物科技有限公司
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