Extract for prevention and treatment of prostatic diseases and preparation method thereof

A technology of extracts and phytosterols, applied in the field of medicine, can solve the problems of high price, reduced drug efficacy, inconvenient treatment and use of patients, etc., and achieve the effect of low cost and simple preparation method

Inactive Publication Date: 2015-08-26
上海兰蒂斯生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the unique anatomical location of the prostate, after oral administration or intramuscular injection, the dose of the drug is very small after reaching the site, and it is difficult to penetrate the prostate capsule, so the effect on the lesion is very small, and the therapeutic effect is minimal
[0003] Since prostatitis mostly has a long course of disease and complex etiology, for bacterial prostatitis, no matter what form of western medicine anti-inflammatory is used, it can only be effective in a short period of time. Over time, bacteria develop resistance to western medicine, and the efficacy will be obvious Reduced, and antibacterial drugs do not work for more than 90% of non-bacterial prostatitis and prostatic pain in prostatitis
Although traditional Chinese medicine sitz bath is effective, it cannot last for a long time, and the treatment is also very troublesome, and the waste of medicine is also great.
Although rectal suppository administration and enema also have therapeutic effects, the natural absorption of the drug is poor, it is inconvenient for patients to use it, and it is easy to cause side effects
Electron therapy, microwave radiofrequency therapy, and infrared radiation therapy have unsatisfactory curative effects, and the treatment is expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Take 1000ml of soybean oil deodorization distillate, add 3000ml of absolute ethanol as a reaction solvent, then add 150ml of catalyst sulfuric acid, heat and reflux in a water bath, cool after reacting for 3h, add an appropriate amount of NaOH solution to neutralize to pH=7, transfer to Stand in a liquid funnel for stratification, the upper oil phase is cooled overnight at 4°C, vacuum filtered, the filter cake is melted with fresh solvent, hot filtered to remove impurities, the filtrate is cooled to crystallize at 4°C, and then filtered to obtain crude soybean sterol extraction The crude soybean sterol extract was recrystallized with 15 times acetone, suction filtered, and dried to obtain 41.50 g of the refined soybean sterol extract. The sum of the β-sitosterol and stigmasterol contents determined by GC method was 71.30%.

Embodiment 2

[0026] Embodiment 2 Get 1000ml of soybean oil deodorization distillate, add 5000ml of methanol as reaction solvent, all the other are the same as in Example 1, get 45.24g of refined soybean sterol extract, the sum of β-sitosterol and stigmasterol content measured by GC method is 67.25% .

Embodiment 3

[0027] Embodiment 3 Get 1000ml soybean oil deodorization distillate, use dehydrated alcohol as recrystallization solvent, all the other are the same as embodiment 1, obtain refined soybean sterol extract 37.13g, GC method measures the sum of β-sitosterol, stigmasterol content is 64.56%.

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PUM

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Abstract

The invention relates to the technical field of medicine, and relates to a phytosterol extract prepared with a soybean deodorized distillate as a raw material. Animal experiments prove that the phytosterol extract has the effects of prevention and treatment of prostatitis, prostatic hyperplasia, prostatic hypertrophy and other related diseases, and can be used for preparation of drugs and food for prevention and treatment of prostatitis, prostatic hyperplasia and prostatic hypertrophy and other related diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to an extract prepared by using soybean deodorized distillate as a raw material, and its use in preparing medicines for preventing and treating prostate diseases. Background technique [0002] Common prostate diseases include prostatitis and benign prostatic hypertrophy, which are common diseases in men and are more common in middle-aged and elderly people. Prostatitis often coexists with chronic seminal vesiculitis, and the lesions can change from acute to chronic, but most of them do not have an acute stage. The main symptoms are perineum, spermatic cord, testicular discomfort, low back pain, mild frequent urination, urethral tingling, urethral discharge, and some patients often have neurasthenia; prostatic hyperplasia is mostly seen in elderly men, and according to statistics, about 70% of men are elderly People suffering from benign prostatic hyperplasia will have serious sympto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J75/00C07J9/00A61K31/575A61K31/56A61P13/08A23L1/30
CPCC07J75/00A23V2002/00A61K31/575C07J9/00
Inventor 栾德刚邙志国栾松平肖智俊
Owner 上海兰蒂斯生物医药科技有限公司
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