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Skin preparation for promoting pigment generation of melanocytes

A melanocyte and skin technology, applied in the field of cell culture, can solve problems such as difficulty in application, inability to effectively and stably form pigment forms, and affecting the growth of cells other than melanocytes.

Active Publication Date: 2015-09-02
SHANGHAI SHANGRUI BIOLOGICAL PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, even with such treatments, normal pigmentation cannot be formed efficiently and stably
In addition, when melanocytes are co-cultured with other skin cells, if these treatments are performed, the growth of cells other than melanocytes will be affected, so it is quite difficult to use

Method used

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  • Skin preparation for promoting pigment generation of melanocytes
  • Skin preparation for promoting pigment generation of melanocytes
  • Skin preparation for promoting pigment generation of melanocytes

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Embodiment Construction

[0019] The skin preparation of the present invention comprises melanocytes with enhanced pigment production ability. Melanocytes are pigment cells that produce melanin. Melanocytes are pigment cells that form melanin. The present invention has no site limitation for the collection of melanocytes, and can be fully obtained from the basal layer of the epidermis or the basal part of the hair follicle. Epidermal keratinocytes are epithelial cells that make up the epidermis, so they can also be obtained from the base of the epidermis or the base of the hair follicle (bulge location).

[0020] Melanocytes are normal cells that divide a limited number of times. For example, after dividing 50 to 80 times, the cell life is over. In the present invention, there is no special regulation on the source of biological species of melanocytes. Mammals such as mice, rats, pigs, and cows are preferably used, or primates such as humans and monkeys are used, and cells of human origin are most p...

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Abstract

The invention relates to a skin preparation. The skin preparation includes a co-culture composition of melanocytes and epidermal cells, the melanocytes in the co-culture composition have enhanced pigment generation ability, and the co-culture composition is cultured to form expansion culture with 1-5 cell layers connected in a two dimensional mode. The invention also relates to a culture solution containing the skin preparation or the extract of the skin preparation, and a preparation method and an application of the skin preparation.

Description

technical field [0001] The invention belongs to the field of cell culture, and in particular relates to a skin preparation containing melanocytes whose pigment production capacity has been enhanced. Background technique [0002] The most important factor in determining skin color is a pigmented substance called melanin. The formation of melanin is produced by melanocytes present in the basal layer of the epidermis. If the production of melanin is abnormally inhibited, or the melanocytes disappear, a kind of acquired depigmentation disease, commonly known as vitiligo, will be formed. Currently, treatments for vitiligo include steroid therapy and photochemotherapy. However, the prognosis of these treatments is not very good, and they all require continuous treatment. [0003] In addition to the above treatments, there are also treatments that take skin or hair follicles from other parts and transplant them. However, this therapy causes a skin defect of the same size as the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/071C12Q1/02
Inventor 徐金华宇山太郎吴复跃何振东
Owner SHANGHAI SHANGRUI BIOLOGICAL PHARMA