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Application of Fingolimod in treatment of periapical periodontitis

A technique for periapical periodontitis and inflammation, applied in the field of prevention and treatment of periapical periodontitis, can solve the problems that the application of periapical periodontitis has not been disclosed or used

Inactive Publication Date: 2015-09-09
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to date, the application of Fingolimod in the treatment of apical periodontitis has not been disclosed or used

Method used

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  • Application of Fingolimod in treatment of periapical periodontitis
  • Application of Fingolimod in treatment of periapical periodontitis
  • Application of Fingolimod in treatment of periapical periodontitis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. Experimental animals and materials:

[0021] 1.1 Experimental animals

[0022] All experimental procedures complied with the guidelines of the Ethics Committee of the School of Stomatology, Wuhan University. Forty-eight female Wistar rats of SPF grade, weighing 200-220 grams, were purchased from the Experimental Animal Center of Hubei Province and raised in separate cages.

[0023] 1.2 Experimental materials

[0024] Fingolimod was purchased from LC laboratories in the United States. With reference to the drug instructions, it was prepared with normal saline to a drug working concentration of 0.4 mg / mL.

[0025] 2. Animal grouping and establishment of rat periapical periodontitis animal model:

[0026] 2.1 Animal grouping

[0027] They were randomly divided into 7-day model control group, 7-day Fingolimod administration group, 21-day model control group, 21-day Fingolimod administration group, 35-day model control group, and 35-day Fingolimod administration group...

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Abstract

The invention discloses an application of Fingolimod in treatment of periapical periodontitis. According to the invention, an in vivo experiment shows that Fingolimod can be used for obviously inhibiting infiltration of local inflammatory cells and bone destruction due to pulp exposing at a lesion of the periapical periodontitis; and S1P1 and RANKL expression level is reduced, local RANKL / OPG ratio is dynamically regulated, and the effect of treating the periapical periodontitis is achieved. The results show that Fingolimod is a medicine capable of effectively treating the periapical periodontitis, and Fingolimod can be used for preparing a medicine used for treating the periapical periodontitis.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of apical periodontitis, and in particular relates to the use of Fingolimod in treating apical periodontitis. Background technique [0002] Apical periodontitis is a common and frequently-occurring disease of the oral cavity. It usually develops from caries or pulp disease. The pathological features are mainly the destruction and absorption of periapical alveolar bone. Apical periodontitis is generally considered to be the result of mixed microbial infection in the root canal, so the main clinical treatment is to remove the infected substances through root canal treatment. However, according to previous X-ray surveys, 25% of the teeth after root canal treatment still have periapical bone destruction; through CT detection, it is found that about 63% of the teeth have periapical bone damage despite perfect root canal treatment. Peripheral bone defects still cannot heal, and eventua...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61P1/02
Inventor 朱玲新肖岚张洁彭彬
Owner WUHAN UNIV
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