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Medical use of bat moth Paecilomyces mutagenics strain ph40 in the treatment of diabetes

A technology of Paecilomyces batmoth and Paecilomyces batmoth, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, and metabolic diseases, etc. Good preventive effect, obvious medical effect

Active Publication Date: 2019-02-01
通化仁生源生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, diabetes treatment drugs are mainly divided into oral drugs and insulin injections. Oral drugs are convenient to administer, but they are accompanied by relatively large side effects. At the same time, the anti-diabetic drugs currently on the market have weak preventive effects on diabetic complications and cannot be completely cured.
Insulin injections are difficult to control, easily cause insulin resistance, and increase the difficulty of disease treatment

Method used

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  • Medical use of bat moth Paecilomyces mutagenics strain ph40 in the treatment of diabetes
  • Medical use of bat moth Paecilomyces mutagenics strain ph40 in the treatment of diabetes
  • Medical use of bat moth Paecilomyces mutagenics strain ph40 in the treatment of diabetes

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Use liquid submerged fermentation method to ferment to produce Paecilomyces hepipialis mutagenic strain PH40. Take 1L of the fermentation broth of Paecilomyces hepipialis mutagenic strain PH40, centrifuge at 5000r / min for 10min, collect the precipitate, freeze-dry it in vacuum, and crush it with a high-speed pulverizer. Pass through a 60-mesh sieve and collect the bacterial powder, which is the mutagenic strain PH40 of Paecilomyces hepialis 1.

Embodiment 2

[0017] Use liquid submerged fermentation method to ferment to produce Paecilomyces hepipipes mutagenic strain PH40, take 1L of the fermentation broth of Paecilomyces hepipialis mutagenic strain PH40, spray dry, collect the bacterial powder, it is Paecilomyces hepialis mutagenic strain PH40 bacterial powder 2.

Embodiment 3

[0019] Use liquid submerged fermentation method to ferment to produce Paecilomyces hepipialis mutagenic strain PH40, take 1L of the fermentation broth of Paecilomyces hepipialis mutagenic strain PH40, centrifuge at 5000r / min for 10min, collect the precipitate, freeze-dry it in vacuum, and crush it with a high-speed grinder Pass through a 60-mesh sieve to collect the bacterial powder, which is the PH40 bacterial powder 3 of the mutant strain of Paecilomyces hepialis.

[0020] Take bacterial powder 3, add sodium bicarbonate, sodium carboxymethyl cellulose and other medicinal auxiliary materials to prepare the PH40 bacterial powder preparation 3 of Paecilomyces hepialis mutagenic strain.

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Abstract

The invention discloses medical application of a paecilomyces hepiali mutant strain PH40 in treating diabetes. The obvious medical effect is achieved. The paecilomyces hepiali mutant strain PH40 is obtained through mutation screening with a paecilomyces hepialid strain (RCEF1429) as an original strain. The paecilomyces hepiali mutant strain PH40 was preserved in China Center for Type Culture Collection in December 26, 2014, and the preservation number is CCTCC M2014670.

Description

Technical field [0001] The invention discloses the medical use of a mutant strain PH40 of Paecilomyces hepipialis in treating diabetes, and belongs to the technical field of traditional Chinese medicine and health care products. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Long-term hyperglycemia causes chronic damage and dysfunction to various tissues of patients, especially eyes, kidneys, heart, blood vessels, and nerves. According to statistics from the International Diabetes Union, in the 1990s, there were approximately 100 million people with diabetes worldwide. By 2007, this number had increased to 246 million. It is estimated that by 2025, 380 million people worldwide will suffer from diabetes. my country is the second-largest country with diabetes after India. According to a survey conducted by the Ministry of Health, my country has approximately 3,000 new diabetic patients every day and 1.2 million new diabetic p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/068A61P3/10
Inventor 孟庆繁刘艳孟令军王娟王迪李龙图滕利荣权宇彤逯家辉
Owner 通化仁生源生物科技股份有限公司