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Compound haqing rectal administration preparation and preparation method thereof

A compound clam green and rectal administration technology, which is applied in the field of medicine, can solve the problems of hepatic and intestinal first-pass effect, low bioavailability, increased drug cost for patients, and low dissolution rate, so as to overcome pain and adverse consequences and maintain drug efficacy The effect of long time, easy to carry and use

Inactive Publication Date: 2015-09-23
SHANXI JIANENG DAHUAYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the clinical curative effect of Compound Haqing Injection is definite, due to its complex composition, it is easy to cause local induration after intramuscular injection, even swelling and pain, secondary infection, and frequent injection can easily lead to gluteal muscle contracture syndrome
In addition, there may be adverse reactions such as allergies, especially in children with higher safety risks
[0004] However, the traditional oral preparations of traditional Chinese medicine have the problems of long disintegration time, low dissolution rate, poor absorption, low intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug and directly affect the therapeutic effect.
In addition, the production process of conventional oral solid Chinese medicine preparations is complicated and the production cost is high, thus increasing the cost of medication for patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Preparation of compound clam green extract:

[0024] Take 40 parts of toad, 50 parts of astragalus, 20 parts of ginkgo, 25 parts of bitter almond, 25 parts of aster, 15 parts of Peucedanum, 15 parts of schisandra, 5 parts of aconite, and 5 parts of black pepper.

[0025] Add water to decoct the medicinal materials twice, the first time for 2 hours, the second time for 1 hour, combine the decoction and filter, and concentrate the filtrate to a thick paste with a relative density of 1.3-1.35. Add ethanol to the thick ointment for three extractions, the amount of ethanol added three times is 60%, 70%, and 80% respectively, let it stand, filter, recover the ethanol, concentrate and dry, crush and pass through a No. 8 sieve to obtain the compound clam green extract .

[0026] 2. Matrix: The choice of matrix can be one or more of lipophilic matrix or hydrophilic matrix. The lipophilic base includes mixed fatty acid glycerides, semi-synthetic fatty acid glycerides, oils s...

Embodiment 2

[0030] suppositories

[0031] 1. Preparation of the compound clam green extract: According to the extract preparation method of Example 1, about 20 g of the extract containing 9 traditional Chinese medicine active pharmaceutical ingredients were prepared in advance for later use.

[0032] 2. Matrix: 36 type mixed fatty acid glycerides, polyoxyethylene (40) monostearate, polyethylene glycol 4000, polyethylene glycol 6000, polyethylene glycol 20000, glycerin gelatin

[0033] 3. Proportion: take g as the unit, by weight, make 100 pieces with drug extract: matrix = 1:1~1:9, that is, each piece contains 0.2g of compound clam green extract, which is equivalent to the original medicinal material 2.0g.

[0034] 4. Accurately weigh the base material according to the ratio given in the formula, heat and melt at 55-60°C, filter and add the prescribed amount of compound clam green extract at 50-55°C with heat preservation and stirring, mix well, and pour into the mold After condensation...

Embodiment 3

[0051] gel

[0052] Prescription: Toad 24g, Astragalus 30g, Ginkgo 12g, Bitter almond 15g, Aster 15g, Peucedanum 9g, Schisandra 9g, Aconite 3g, Black pepper 3g

[0053] Preparation method: (1) Preparation of compound clam green extract: according to Example 1, 12 g of compound clam green extract containing 9 active ingredients of traditional Chinese medicines were prepared in advance for use.

[0054] (2) Swell 0.5g of carbomer in 78g of purified water, let it stand until the swelling is complete, add triethanolamine to adjust the pH value to 4-7, and add 10g of propylene glycol to make a matrix for later use; mix the compound clam green extract with the above The matrix is ​​mixed evenly, divided into packages, and ready to serve.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and provides a compound haqing rectal administration preparation and a preparation method thereof. The compound haqing rectal administration preparation is prepared by adopting active medicinal component extract of toad, astragalus membranaceus, ginko seeds, semen armeniacae amarae, aster, radix peucedani, schisandra chinensis, radix aconiti carmichaeli and black pepper as raw materials on applicable medical carriers. The compound haqing rectal administration preparation is used for treating cough of deficiency lung, asthma, excessive phlegm, aged chronic pneumonia, emphysema, asthmatic bronchitis and the like, has an effect for preventing repeated cold and is suitable for being widely applied clinically.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation for rectal administration and a preparation method thereof. Background technique [0002] The main components of Compound Haqing Injection are toad, astragalus, ginkgo, bitter almond, aster, peucedanum, schisandra, aconite, black pepper, etc. Among them, astragalus has the effect of nourishing qi and strengthening the surface, and toad, bitter almond, and aster have the effect of relieving cough and asthma , Qianhu, Schisandra, and Fuzi have the effect of warming and resolving phlegm. Especially toads contain catecholamines and indole alkyls, which can slow down the heart rate, strengthen the heart, and have hormone-like anti-inflammatory effects. It is widely used clinically for cough due to lung deficiency, asthma with excessive phlegm, elderly chronic bronchitis, emphysema, asthmatic bronchitis, etc. It also has a preventive effect on those who suf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/736A61P11/14A61P11/10A61P11/00
Inventor 耿福能
Owner SHANXI JIANENG DAHUAYU PHARMA CO LTD
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