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Pharmaceutical composition for preventing and treating diabetic complications and preparation method thereof

A technology for diabetic nephropathy and drugs, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as prone to hyperkalemia, hypercreatinine, and inability to effectively prevent the progression and deterioration of the disease. To achieve the effect of easy industrial application, simple operation and stable drug quality

Active Publication Date: 2019-03-26
GUANGZHOU CONSUN MEDICINE R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, symptomatic treatment and combination drugs are mainly used clinically, such as hypoglycemic, antihypertensive, lipid-lowering, AR / AGEs inhibitors and renin-angiotensin-aldosterone system (RAAS) inhibitors, etc. Clinical problems such as diabetes complications such as high blood pressure and proteinuria, but it cannot effectively prevent the progression and deterioration of the disease, and it is prone to side effects such as hyperkalemia and hypercreatinine, which limits its long-term clinical use

Method used

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  • Pharmaceutical composition for preventing and treating diabetic complications and preparation method thereof
  • Pharmaceutical composition for preventing and treating diabetic complications and preparation method thereof
  • Pharmaceutical composition for preventing and treating diabetic complications and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] A pharmaceutical composition for the prevention and treatment of diabetic complications in this embodiment comprises the following raw materials:

[0028]

[0029]

[0030] The preparation method of the above-mentioned pharmaceutical composition for preventing and treating diabetic complications comprises the following steps:

[0031] Pass 3′-methoxydaididin through 80 mesh sieve, mix with lactose and starch, add appropriate amount of water and granulate the powder, after drying, sift the granules and mix with appropriate amount of water and magnesium stearate, press Slice and serve.

Embodiment 2

[0033] A pharmaceutical composition for the prevention and treatment of diabetic complications in this embodiment comprises the following raw materials:

[0034] 3′-Methoxydaidzin 1mg

[0035] Microcrystalline Cellulose 500mg

[0036] Starch 500mg,

[0037] The preparation method of the above-mentioned pharmaceutical composition for preventing and treating diabetic complications comprises the following steps:

[0038] After uniformly mixing 3'-methoxydaidzin with various carriers, adding an appropriate amount of water to make a soft material, granulating, drying, sizing, and subpackaging to obtain the product.

Embodiment 3

[0040] A pharmaceutical composition for the prevention and treatment of diabetic complications in this embodiment comprises the following raw materials:

[0041]

[0042] The preparation method of the above-mentioned pharmaceutical composition for preventing and treating diabetic complications comprises the following steps:

[0043] Pass 3′-methoxydaidzein through 80 mesh sieve, mix with lactose, starch, dextrin, add pre-prepared HPMC solution to make soft material, granulate, dry, sift the wet mixture and dry, Then sieve for granulation, add magnesium stearate, then compress the mixture into tablets, each tablet weighs 200 mg, and the active ingredient content is 20 mg. The tablet is used for the prevention and treatment of hyperuria and diabetic nephropathy, and has good effect.

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Abstract

The invention relates to a pharmaceutical composition for controlling diabetic complications and a preparation method of the pharmaceutical composition. The activated components of the pharmaceutical composition include 3'-methoxyl daidzin and / or 3'-methoxyl daidzein. Through pharmacology experiments, it is found that the 3'-methoxyl daidzin and the 3'-methoxyl daidzein have excellent new medical application for controlling the diabetic complications and provide new control candidate medicine for patients suffering from the diabetic complications, and the optimal effect of controlling the diabetic complications can be achieved particularly by using the 3'-methoxyl daidzin and the 3'-methoxyl daidzein in cooperation according to the weight ratio.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for preventing and treating diabetic complications and a preparation method thereof. Background technique [0002] Diabetes and diabetic complications (Diabetes chronic complications, DCC) have become a serious threat to human health diseases. With the change of people's living habits, the prevalence of diabetes and its complications is increasing year by year. Therefore, the prevention and treatment of diabetes and its complications has become an important subject of human research. [0003] Diabetes is a common and multiple disease, and its harm to human health is mainly manifested in a variety of chronic complications, including diabetic nephropathy, diabetic eye disease, diabetic heart disease, diabetic neuropathy and other microvascular diseases, etc. . According to the statistics of the American Diabetes Association (ADA), the incidence of compl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P3/10A61K31/352
Inventor 王汝上郑兆广朱荃何宝段婷婷顾斐程慧荃胡琴杨琳琳陈丹扬高雪晖屈夏菁杨丹
Owner GUANGZHOU CONSUN MEDICINE R & D CO LTD