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Pharmaceutical composition for controlling diabetic complications and preparation method of pharmaceutical composition

A technology for diabetes and complications, which is applied in the field of pharmaceutical compositions for the prevention and treatment of diabetes complications and its preparation, can solve the problems of inability to effectively prevent the progress and deterioration of the disease, prone to hyperkalemia, hypercreatinine, etc., and achieve industrial convenience The effect of application, stable drug quality and convenient use

Active Publication Date: 2015-09-30
GUANGZHOU CONSUN MEDICINE R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, symptomatic treatment and combination drugs are mainly used clinically, such as hypoglycemic, antihypertensive, lipid-lowering, AR / AGEs inhibitors and renin-angiotensin-aldosterone system (RAAS) inhibitors, etc. Clinical problems such as diabetes complications such as high blood pressure and proteinuria, but it cannot effectively prevent the progression and deterioration of the disease, and it is prone to side effects such as hyperkalemia and hypercreatinine, which limits its long-term clinical use

Method used

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  • Pharmaceutical composition for controlling diabetic complications and preparation method of pharmaceutical composition
  • Pharmaceutical composition for controlling diabetic complications and preparation method of pharmaceutical composition
  • Pharmaceutical composition for controlling diabetic complications and preparation method of pharmaceutical composition

Examples

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Effect test

Embodiment 1

[0027] The present embodiment is a pharmaceutical composition for preventing and treating diabetic complications, comprising the following raw materials:

[0028]

[0029]

[0030] The preparation method of the above-mentioned pharmaceutical composition for preventing and treating diabetic complications, comprising the following steps:

[0031] Pass 3'-methoxydaidzein through an 80-mesh sieve, mix with lactose and starch, add an appropriate amount of water and granulate the powder, after drying, sieve the granules and mix with an appropriate amount of water and magnesium stearate, press Get a slice.

Embodiment 2

[0033] The present embodiment is a pharmaceutical composition for preventing and treating diabetic complications, comprising the following raw materials:

[0034] 3'-Methoxydaidzein 1mg

[0035] Microcrystalline Cellulose 500mg

[0036] Starch 500mg,

[0037] The preparation method of the above-mentioned pharmaceutical composition for preventing and treating diabetic complications, comprising the following steps:

[0038] After mixing 3'-methoxydaidzein and each carrier uniformly, adding an appropriate amount of water to make soft material, granulating, drying, granulating, and packaging.

Embodiment 3

[0040] The present embodiment is a pharmaceutical composition for preventing and treating diabetic complications, comprising the following raw materials:

[0041]

[0042] The preparation method of the above-mentioned pharmaceutical composition for preventing and treating diabetic complications, comprising the following steps:

[0043] Pass 3'-Methoxydaidzein through an 80-mesh sieve, mix with lactose, starch and dextrin, add pre-prepared HPMC solution to make soft material, granulate, dry, sieve and dry the wet mixture, After sieving and granulating again, magnesium stearate is added, and then the mixture is compressed into tablets, each tablet weighing 200 mg and having an active ingredient content of 20 mg. The tablet is used for the prevention and treatment of hyperproteinemia and diabetic nephropathy, and has good effect.

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Abstract

The invention relates to a pharmaceutical composition for controlling diabetic complications and a preparation method of the pharmaceutical composition. The activated components of the pharmaceutical composition include 3'-methoxyl daidzin and / or 3'-methoxyl daidzein. Through pharmacology experiments, it is found that the 3'-methoxyl daidzin and the 3'-methoxyl daidzein have excellent new medical application for controlling the diabetic complications and provide new control candidate medicine for patients suffering from the diabetic complications, and the optimal effect of controlling the diabetic complications can be achieved particularly by using the 3'-methoxyl daidzin and the 3'-methoxyl daidzein in cooperation according to the weight ratio.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for preventing and treating diabetic complications and a preparation method thereof. Background technique [0002] Diabetes and diabetic complications (Diabetes chronic complications, DCC) have become a serious disease that endangers human health. With the change of people's living habits, the prevalence of diabetes and its complications is increasing year by year. Therefore, the prevention and treatment of diabetes and its complications has become an important subject of human research. [0003] Diabetes is a common and multiple disease. Its harm to human health is mainly manifested in a variety of chronic complications, including diabetic nephropathy, diabetic eye disease, diabetic heart disease, diabetic neuropathy and other microvascular diseases. . According to the statistics of the American Diabetes Association (ADA), the risk of complic...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10A61K31/352
Inventor 王汝上郑兆广朱荃何宝段婷婷顾斐程慧荃胡琴杨琳琳陈丹扬高雪晖屈夏菁杨丹
Owner GUANGZHOU CONSUN MEDICINE R & D CO LTD