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Ambroxol hydrochloride capsule and preparation method thereof

A technology of ambroxol hydrochloride capsules and ambroxol hydrochloride, which can be used in pharmaceutical formulations, respiratory diseases, drug combinations, etc., can solve problems such as the influence of main drug stability, unknown side effects, etc., to reduce toxic side effects and stabilize drug quality. Effect

Inactive Publication Date: 2015-05-13
SHANGHAI HUAYUAN ANHUI RENJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When preparing the tablets, granules and capsules of ambroxol hydrochloride, the components of the excipients used are too complicated, which will affect the stability of the main drug and may cause unknown side effects

Method used

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  • Ambroxol hydrochloride capsule and preparation method thereof
  • Ambroxol hydrochloride capsule and preparation method thereof
  • Ambroxol hydrochloride capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A kind of ambroxol hydrochloride capsule, comprises following raw material component (by weight percentage):

[0018]

[0019] A kind of preparation method of better ambroxol hydrochloride capsules, the steps are:

[0020] (1) After ambroxol hydrochloride and starch are crossed through a 100 mesh sieve respectively, take by prescription and fully mix to obtain mixed powder;

[0021] (2) Add carboxypropyl methylcellulose to ethanol to dissolve and stir evenly, add the mixed powder of step (1) and stir to form a soft material;

[0022] (3) passing the above-mentioned soft material through a 20-mesh sieve to granulate, and drying at a temperature of 40° C., passing through a 40-mesh sieve for granulation, and sieving out fine powder to obtain granules;

[0023] (4) Dissolve sodium carboxymethyl cellulose with ethanol to obtain a coating solution, place the granules in step (3) in a coating pan, roll the coating pan, blow hot air while spraying the coating solution, and...

Embodiment 2

[0027] A kind of ambroxol hydrochloride capsule, comprises following raw material component (by weight percentage):

[0028]

[0029]

[0030] A kind of preparation method of better ambroxol hydrochloride capsules, the steps are:

[0031] (1) After ambroxol hydrochloride and starch are crossed through a 100 mesh sieve respectively, take by prescription and fully mix to obtain mixed powder;

[0032] (2) Add carboxypropyl methylcellulose to ethanol to dissolve and stir evenly, add the mixed powder of step (1) and stir to form a soft material;

[0033] (3) Pass the above-mentioned soft material through a 20-mesh sieve to granulate, and dry at a temperature of 35° C., pass through a 40-mesh sieve for granulation, and sieve out fine powder to obtain granules;

[0034] (4) Dissolve sodium carboxymethyl cellulose with ethanol to obtain a coating solution, place the granules in step (3) in a coating pan, roll the coating pan, spray the coating solution while blowing hot air, an...

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PUM

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Abstract

The invention relates to an ambroxol hydrochloride capsule and a preparation method thereof. By optimizing accessories, a simple prescription is adopted while guaranteeing the effective slow release of drugs, so that the stable quality of ambroxol hydrochloride drugs is guaranteed and the toxic and side effects caused by the accessories are reduced.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to an ambroxol hydrochloride capsule and a preparation method thereof. Background technique [0002] Ambroxol hydrochloride is a new active product of ambroxol fused with hydrochloric acid and formed into a salt. It is a new mucus-dissolving drug. It has the functions of dissolving and secreting mucus and promoting mucus excretion, and can stimulate the formation of respiratory surfactant at the same time. And regulate the secretion of serous and mucus, reduce the adhesion of sputum and cilia, and then eliminate the viscous secretions in the respiratory tract and reduce the retention of mucus, thus significantly promoting expectoration. It is suitable for acute and chronic respiratory diseases accompanied by abnormal sputum secretion and poor expectoration function. [0003] Due to the presence of primary amines in ambroxol hydrochloride molecules, wh...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/137A61P11/12A61K47/38
Inventor 钱令刘俊华齐鸿达
Owner SHANGHAI HUAYUAN ANHUI RENJI PHARMA