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Pharmaceutical composition for treating diabetes and preparation method thereof

A composition and diabetes technology, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of reduced GP and G6Pase enzyme activity and expression, and achieve stable drug quality and convenient clinical application. Effect

Active Publication Date: 2013-11-20
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The expression of GP and G6Pase was reduced at the level of mRNA and immunoreactive protein, and the enzyme activities of GP and G6Pase were also reduced

Method used

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  • Pharmaceutical composition for treating diabetes and preparation method thereof
  • Pharmaceutical composition for treating diabetes and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Preparation of pharmaceutical tablet of the present invention

[0029] prescription:

[0030] Glimepiride 2.0g

[0031] Geniposide 2.5 g

[0032] Lactose 67.5 g

[0033] Microcrystalline Cellulose 20.0g

[0034] Sodium carboxymethyl starch 3.0g

[0035] Povidone K30 5.0g

[0036] Makes 1000 pieces

[0037] Operation: Take the pulverized and sieved 80-mesh glimepiride, geniposide, lactose, and microcrystalline cellulose according to the prescription amount, mix thoroughly with the equal volume incremental mixing method, and then pulverize and sieve. Take povidone K30, add distilled water and heat it to make 5% povidone K30 solution, add it to the mixed powder to make soft material, granulate with 20 mesh sieve, dry at 60°C for 4 hours, collect the granules, add carboxymethyl starch Sodium, mixed evenly, granulated with 18 mesh sieve, pressed into tablets, ready to be obtained.

[0038] Prove the beneficial effect of the present invention below by con...

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Abstract

The invention provides a pharmaceutical composition for treating diabetes. The pharmaceutical composition comprises a medicament prepared by glimepiride and geniposide as main components, by weight ratio: 1-10 parts of glimepiride, and 1-20 parts of geniposide. The invention also provides a preparation method and applications of the pharmaceutical composition. With compatible use of glimepiride and geniposide, the pharmaceutical can play a synergistic pharmacological function, is convenient for clinical application, and provides a new choice for clinics.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes mellitus is a common endocrine disease, which is caused by absolute or relative insulin deficiency or decreased sensitivity of target cells to insulin, mainly caused by disturbance of glucose metabolism, followed by disturbance of fat, protein, water and electrolyte metabolism. Type 2 diabetes is the most common type of diabetes, and its incidence is increasing, mainly due to changes in lifestyles in developed and developing countries, such as the development of unhealthy eating habits and lack of exercise. The incidence of diabetes is as high as 7-8%, and the incidence gradually increases with age. [0003] Glimepiride is the third-generation sulfonylurea long-acting antidiabetic drug, and its mechanism of action is through binding to the sulfonylurea receptor (a protein with a relative molecular mass of...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/20A61P3/10A61K31/64
Inventor 石万棋郎天琼邓聪
Owner SICHUAN GUOKANG PHARMA