COX-1 gene polymorphism site related to aspirin resistance and application
A technology of COX-1 and aspirin, which is applied in the field of medical disease treatment drug selection, can solve problems such as uncertain gene polymorphisms, and achieve the effect of reducing the recurrence rate of stroke
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0027] Discovery of the COX-1 gene polymorphism (A842G) associated with aspirin resistance:
[0028] The data of stroke patients from 2010 to 2014 were retrieved from the stroke database, and according to the diagnostic criteria of ischemic stroke, patients diagnosed with ischemic stroke were screened, and aspirin was further selected for secondary prevention (secondary prevention is for patients with cerebral palsy). For patients with stroke symptoms or after stroke, these people need to prevent reoccurrence of stroke) as the total sample (5033 people in total).
[0029] 1. Determine the number of people with stroke recurrence in the total sample, and explore the relationship between the COX-1 (A842G) gene polymorphism and stroke recurrence in the total sample (Table 2);
[0030] 2. Among the total samples, patients who came to the hospital for reexamination (including relapsed and non-relapsed patients, a total of 3429 patients), collected peripheral blood from the patients,...
Embodiment 2
[0046] Application of the primers for the COX-1 gene polymorphism site (A842G) related to aspirin resistance in the preparation of a kit for screening aspirin resistance patients:
[0047] All patients with ischemic stroke for the first time were given aspirin for secondary prevention, and the patients were followed up 3 months later to detect the ARU and stroke recurrence of each patient. At the same time, the peripheral blood of the patients was collected to detect the presence of COX-1 (A842G) polymorphism by gene sequencing, and the incidence of aspirin resistance in mutant and wild-type patients was analyzed.
[0048] The study began in August 2013, and the deadline for case inclusion was August 2014. According to the diagnostic criteria for ischemic stroke, patients diagnosed with ischemic stroke were selected as the research objects, and the following tasks were completed:
[0049] 1. According to the guidelines for the secondary prevention of ischemic stroke, aspirin w...
Embodiment 3
[0059] Discovery of other genetic polymorphisms associated with aspirin resistance:
[0060] 1) Discovery of the GPⅠa gene polymorphism (C807T) associated with aspirin resistance:
[0061] With the same stroke database, blood sample and method as in Example 1, detect the relationship between the polymorphism of the GPⅠa (C807T) gene and stroke recurrence in the total sample (5033 people in total, the same as in Example 1) (Table 6); The relationship between the polymorphism of the GPIa (C807T) gene and ARU ≥ 550 in patients (including relapsed and non-relapsed patients, a total of 3429 people, the same as in Example 1) was reexamined (Table 5).
[0062] The results showed that among patients with ischemic stroke who took aspirin for secondary prevention, compared with wild-type patients, the ARU value of aspirin response unit in patients with GPⅠa(C807T) mutation group was significantly higher, and the number of patients with ARU≥550 was significantly higher than that in wild-...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com