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Antibacterial healing promoting material for oral cavities and application of antibacterial healing promoting material

A healing material and a technology of antibacterial effect, applied in the field of medical supplies, can solve problems such as accelerated lesion recovery, poor effect of promoting wound healing, and imbalance of normal oral flora, so as to promote repair of damaged tissue, inhibit reproduction and attachment, and accelerate lesion recovery. The effect of rehabilitation

Inactive Publication Date: 2015-10-07
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an antibacterial and healing-promoting material for oral application and its application to overcome the problems of drug resistance and normal oral flora imbalance caused by the current application of antibiotics in the treatment of periodontal disease. At the same time, the material has the ability to promote the healing of damaged tissues. The repair function can accelerate the recovery of lesions and overcome the poor effect of oral ulcer drugs in promoting wound healing. It is a new material that is superior to existing treatment methods

Method used

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  • Antibacterial healing promoting material for oral cavities and application of antibacterial healing promoting material
  • Antibacterial healing promoting material for oral cavities and application of antibacterial healing promoting material

Examples

Experimental program
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Effect test

Embodiment 1

[0010] Preparation of oral antibacterial and healing-promoting material A: Pour 0.2g polypeptide into a 500ml beaker, add 1.5% CaCl 2 Solution 3ml, then add 167ml of purified water, stir until the polypeptide is completely dissolved. Slowly add 8g of hydroxyethyl chitin, stir evenly, and the solution is gelatinous at this time. Add 30ml 1% I 2 / KI solution, stirred evenly, at this time the glue solution was brown, after the color of the glue solution retreated completely, it was divided into sterile syringes, and finally the colloidal oral antibacterial antibacterial and healing promoting material A was obtained through irradiation sterilization.

[0011] In this example, the mass ratio of hydroxyethyl chitin to antimicrobial peptides is 1-50:1, the molar ratio to metal ions is 1-200:1, and the molar ratio to iodine is 1-15:1; Chitin can also use one of the following chitin / chitosan derivatives: hydroxypropyl chitin / chitosan, hydroxyethyl chitosan, carboxymethyl chitin / chito...

Embodiment 2

[0013] Preparation of oral antibacterial and healing-promoting material B: Pour 0.15g of polypeptide into a 500ml beaker, add 157ml of purified water, and add 2% CaCl 2 Solution 3ml, stir until the polypeptide is completely dissolved. Slowly add 7.5g carboxymethyl chitin, stir evenly, and the solution is gelatinous at this time. Add 40ml 1% I 2 / KI solution, stirred evenly, at this time the glue solution was brown, after the color of the glue solution faded completely, the liquid was freeze-dried, and finally sterilized by irradiation to obtain spongy oral cavity antibacterial and healing-promoting material B.

[0014] In this example, the mass ratio of hydroxyethyl chitin to antibacterial peptide is 1-50:1, the molar ratio to metal ion is 1-200:1, and the molar ratio to iodine is 1-15:1; carboxymethyl Chitin can also use one of the following chitin / chitosan derivatives: hydroxypropyl chitin / chitosan, hydroxyethyl chitin / chitosan, carboxymethyl chitosan, carboxyethyl chitin ...

Embodiment 3

[0016] Preparation of oral antibacterial and healing-promoting material C: Pour 0.05g of polypeptide into a 200ml beaker, add 55ml of purified water, and add 0.5% ZnCl 2 Solution 5ml, stir until the polypeptide is completely dissolved. Slowly add 2g carboxymethyl chitosan, stir evenly, and the solution is gelatinous now. Add 40ml 0.25% I 2 / KI solution, stir evenly, the glue solution is brown at this time, after the color of the glue solution fades completely, spread the liquid on the surface of a smooth glass plate, dry, cut, and irradiate to obtain a film-shaped oral antibacterial Healing material C.

[0017] In this embodiment, the mass ratio of carboxymethyl chitosan to antimicrobial peptide is 1~50:1, the molar ratio to metal ion is 1~200:1, and the molar ratio to iodine is 1~15:1; Chitosan can also use one of the following chitin / chitosan derivatives: hydroxypropyl chitin / chitosan, hydroxyethyl chitin / chitosan, carboxymethyl chitin, carboxyethyl Chitin / Chitosan, Succ...

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Abstract

Disclosed is an antibacterial healing promoting material for oral cavities. The antibacterial healing promoting material is characterized by comprising a water-soluble chitin / chitosan derivative, metal ions and antibacterial peptide and iodine (I2) with antibacterial effects; the antibacterial healing promoting material for the oral cavities can be powdery or spongy or colloidal or can be in the shape of a membrane; the water-soluble chitin / chitosan derivative is a derivative of hydroxypropyl chitin / chitosan, hydroxyethyl chitin / chitosan, carboxymethyl chitin / chitosan, carboxyethyl chitin / chitosan and succinyl chitin / chitosan or can be a mixture of two derivatives of the hydroxypropyl chitin / chitosan, the hydroxyethyl chitin / chitosan, the carboxymethyl chitin / chitosan, the carboxyethyl chitin / chitosan and the succinyl chitin / chitosan; the metal ions are a type of water-soluble zinc salt / calcium salt / aluminum salt / iron salt or mixtures of optional two types of the water-soluble zinc salt / calcium salt / aluminum salt / iron salt. The antibacterial healing promoting material has the advantages that good antibacterial and wounded tissue repair promoting effects can be realized, drug resistance can be prevented when the antibacterial healing promoting material is used for preventing and treating periodontal diseases and oral ulcer, and imbalance of normal flora in the oral cavities can be prevented; the antibacterial healing promoting material is obviously superior as compared with the traditional drug, is a novel material superior to existing treatment modes and has high application and development value.

Description

technical field [0001] The invention belongs to the field of medical supplies, and relates to an oral antibacterial and healing-promoting material and an application thereof. Background technique [0002] Periodontal disease and oral ulcers are very common oral diseases. The main cause of periodontal disease is bacterial infection. Bacteria accumulate on the tooth surface and gingival sulcus in the form of plaque. Microorganisms and their metabolites stimulate periodontal tissue and cause periodontitis. Its main symptoms are bleeding, redness and swelling of the gums. Purulent, receding gums, loose teeth or even loss of teeth, resulting in tooth loss, affecting chewing and digestive functions, the disease can also be used as an infection focus to cause or aggravate certain systemic diseases, such as diabetes, cardiovascular disease, infective endocarditis , Respiratory diseases, etc., have great harm to health. The occurrence of oral ulcers is related to factors such as ba...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 刘万顺邓婧宋福来宋佳崔士斌冯伊琳
Owner 青岛博益特生物材料股份有限公司
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