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Method and kit for evaluating prostatic cancer endocrinotherapy effect

A technology for endocrine therapy and prostate cancer, which is applied in biochemical equipment and methods, and the determination/inspection of microorganisms. It can solve the problems of insufficient accuracy and sensitivity of miRNA markers, and achieve the effect of improving accuracy.

Inactive Publication Date: 2015-10-07
冯宁翰
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] The invention provides a method and a kit for evaluating the effect of endocrine therapy on prostate cancer, which solves the technical problem that existing miRNA markers have insufficient accuracy and sensitivity

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  • Method and kit for evaluating prostatic cancer endocrinotherapy effect

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Embodiment Construction

[0014] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0015] Embodiments of the present invention provide a method for evaluating the effect of endocrine therapy for prostate cancer, such as figure 1 shown, including:

[0016] Step 101, detecting the relative content of miR-4638 in the patient;

[0017] Wherein, step 101 includes two situations:

[0018] 1. For patients with suspected prostate cancer, detect the relative content of miR-4638 in the serum of patients with suspected prostate cancer;

[0019] 2. For patients who have been diagnosed with prostate cancer, detect the relative content of miR-4638 in prostate biopsy specimens or radical surgery specimens.

[0020] Among them, the main ways to obtain prostate cancer specimens are:

[0021] Take a biopsy specimen diagnosed ...

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Abstract

The invention relates to the field of early diagnosis and prognosis of prostatic cancer, and discloses a method and kit for performing early diagnosis on prostatic cancer and evaluating prostatic cancer endocrinotherapy effect. The relative content of miR-4638 of the patient is detected, and the sickness condition of the prostatic cancer patient is evaluated according to the relative content of miR-4638. The method and kit enhance the prostatic cancer detection accuracy and sensitivity of the miRNA marker.

Description

technical field [0001] The invention relates to the field of early diagnosis of prostate cancer, in particular to a method and kit for evaluating the effect of endocrine therapy on prostate cancer. Background technique [0002] MicroRNA (miRNA) is a class of non-coding single-stranded microRNA molecules encoded by endogenous genes with a length of about 22 nucleotides, which have various important regulatory functions in cells. Each miRNA can have multiple target genes, and several miRNAs can also regulate the same gene. This complex regulatory network can not only regulate the expression of multiple genes through one miRNA, but also finely regulate the expression of a gene through the combination of several miRNAs. It is assumed that miRNAs regulate one-third of human genes. Because of its high degree of conservation, spatiotemporal specificity, stability, and tissue specificity, MicroRNA is superior to other biomarkers such as proteins and DNA fragments, and is widely us...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 冯宁翰吕永杰鲁晓杰毛雪莹汪洋邵宁温丽婷徐新宇王纯才包文平
Owner 冯宁翰
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