Astragalus formula granule mixing process online quality control method

A quality control method and mixing process technology, which can be used in measurement devices, preparation of samples for testing, material analysis by optical means, etc., and can solve problems affecting the safety, effectiveness, and stability of final products.

Inactive Publication Date: 2015-10-07
ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD
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  • Summary
  • Abstract
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Problems solved by technology

If the mixing is uneven, it will affect the safety, effectiveness and stability of the final product.

Method used

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  • Astragalus formula granule mixing process online quality control method
  • Astragalus formula granule mixing process online quality control method
  • Astragalus formula granule mixing process online quality control method

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Embodiment Construction

[0016] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0017] see Figure 1 to Figure 3 , The invention provides an online quality control method for the mixing process of astragalus formula granules, comprising the steps of:

[0018] (1) Collect near-infrared spectrum online: collect the near-infrared spectrum of the mixing process of Astragalus extract and excipients online, and feed the collected near-infrared spectrum to the control system through the communication interface and the PLC control module;

[0019] (2) Spectral preprocessing: Due to the influence of the en...

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Abstract

The invention discloses an astragalus formula granule mixing process online quality control method, which comprises the steps of: collecting the near infrared spectrum of an astragalus extract and auxiliary material mixing process on line, and feeding back the collected near infrared spectrum to a control system; conducting spectrum pretreatment; establishing a model of all quality control indexes, and investigating the model performance by the model evaluation indexes; applying the established model to online analysis of the variation trend of each quality control index in the mixing process; and linking an near infrared spectrometer with the control system to realize online quality control. In the way, the method provided by the invention applies the near infrared online detection technology to the astragalus formula granule mixing process, and provides the basis and effective guidance for realizing mixing homogeneity online detection and mixing endpoint online judgment in the mixing process and online control and endpoint judgment of the astragalus formula granule mixing process.

Description

technical field [0001] The invention relates to the field of preparation of traditional Chinese medicine formula granules, in particular to an online quality control method for the mixing process of astragalus formula granules. Background technique [0002] Astragalus, mainly contains saponins, flavonoids, etc., can invigorate Qi and solidify the surface, support toxins and expel pus, diuresis, and build muscle. Can promote body metabolism, anti-fatigue, promote the renewal of serum and liver protein; have obvious diuretic effect, can eliminate urinary protein in experimental nephritis; can improve the phenomenon of anemia animals; can increase hypoglycemia, reduce hyperglycemia; can stimulate breathing; can It can enhance and regulate the immune function of the body, promote the interferon system, and improve the body's disease resistance; it has a mild inhibitory effect on cytopathies caused by various viruses such as influenza virus, and has a protective effect on influen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N1/28G01N30/88
Inventor 高波罗川
Owner ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD
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