Methods and compositions of protein antigens for the diagnosis and treatment of leptospirosis

A technology for leptospirosis and leptospirosis, which can be used in chemical instruments and methods, disease diagnosis, bacterial antigen components, etc., and can solve problems such as identification and provision of diagnosis and prevention.

Inactive Publication Date: 2015-10-21
RGT UNIV OF CALIFORNIA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the methods fail to specifically identify and provide Leptospira antigens that can be used for diagnostic and prophylactic purposes, generating particularly strong and / or broad antibody responses

Method used

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  • Methods and compositions of protein antigens for the diagnosis and treatment of leptospirosis
  • Methods and compositions of protein antigens for the diagnosis and treatment of leptospirosis
  • Methods and compositions of protein antigens for the diagnosis and treatment of leptospirosis

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Embodiment

[0065] method

[0066] Human study protocol: The protocol was approved by the institutional review board committees of Yale University and Oswaldo Cruz Foundation. Samples were obtained from infected patients and healthy individuals living in communities with high endemic transmission of leptospirosis and written informed consent was provided to the participants. Blood donors from the city of Salvador were anonymous. Sera from healthy individuals in the United States were obtained from anonymous volunteers at the General Clinical Research Center at the University of California, Irvine. After collection, each patient was assigned a code number such that all samples were anonymized prior to use.

[0067] Human samples: Evaluation was performed using a pool of 114 control human serum samples and 160 laboratory-confirmed leptospirosis case sera. Control samples were (i) 29 sera from healthy volunteers in California, USA, where leptospirosis was not endemic; (ii) blood donors fr...

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Abstract

Novel immunodominant antigenic proteins and peptides associated with associated with leptospirosis were identified using a proteome array based on expression of ORFs from a Leptospira genome. Compositions, methods, and uses of such antigenic proteins and peptides in the diagnosis and staging of leptospirosis infection and in compositions, methods, and uses of such antigenic proteins and peptides in prophylactic and therapeutic vaccines are disclosed.

Description

[0001] This application claims priority to Provisional Application No. 61 / 736391, filed December 12, 2012. The entire contents of these and all other cited extrinsic materials are hereby incorporated by reference. To the extent that a definition or use of a term in a reference incorporated by reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein controls. technical field [0002] The field of the invention is compositions and methods for the diagnosis and treatment of various conditions and diseases, especially leptospirosis. Background technique [0003] Leptospirosis is a widespread serious disease caused by infection with bacteria of the genus Leptospira. The disease is transmitted to humans through contact with infected domestic or wild animals or through contact with their urine. A wide variety of animal species can serve as a reservoir for the bacteria. Thus, human leptospirosis is often con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/02C07K14/20
CPCC07K14/20A61K39/0225A61P31/04G01N33/56911G01N2333/20G01N2469/20G01N2800/26
Inventor P·菲尔格纳梁小武A·柯小E·A·旺德
Owner RGT UNIV OF CALIFORNIA
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