Application of lipopolysaccharide-binding protein in the preparation of rheumatoid arthritis-related drugs

A technology for combining proteins and lipopolysaccharides, which can be used in drug combinations, peptide/protein components, antipyretics, etc., to solve problems such as no correlation and no research on mutual relationships

Active Publication Date: 2018-08-28
PEOPLES HOSPITAL PEKING UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] The existing technology believes that the concentration of lipopolysaccharide-binding protein in the blood of patients can be used as an important reference index for judging damage and prognosis, but no one has studied the relationship between LBP and immune system diseases, especially the relationship between LBP and rheumatoid arthritis. There are no relevant experimental results to prove that there is a correlation between the two

Method used

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  • Application of lipopolysaccharide-binding protein in the preparation of rheumatoid arthritis-related drugs
  • Application of lipopolysaccharide-binding protein in the preparation of rheumatoid arthritis-related drugs
  • Application of lipopolysaccharide-binding protein in the preparation of rheumatoid arthritis-related drugs

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Embodiment

[0029] Example: Research on the role of lipopolysaccharide-binding protein in the diagnosis and disease activity of rheumatoid arthritis

[0030] 1. Case and control sample selection criteria

[0031] The 120 RA patients were all inpatients in the Department of Rheumatology and Immunology, Peking University People's Hospital from 2013 to 2014. They met the RA classification criteria established by the American College of Rheumatology (ACR) in 1987. Among them, 92 were female and 28 were male. 29 to 89 years old, with an average age of 60.27±10.59 years, and the course of disease ranged from 1 to 51 years, with an average of 12.16±8.69 years. A total of 32 patients with osteoarthritis (Osteoarthritis, OA), 30 patients with systemic lupus erythematosus (SLE), and 30 patients with primary Sjögren's syndrome were selected. syndrome, pSS) patients as the disease control group, and 51 healthy volunteers as the healthy control group (HC). The sera of each group were derived from t...

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Abstract

According to the invention, 26 types of proteins have differential expression in immune complexes of serums of an RA (rheumatoid arthritis) patient and a normal collator through the mass spectrometry, wherein LBP (lipopolysaccharide binding protein) is proved to be increased in RA circulating immune complexes; according to a further research, LBP is a specificity serum marker of RA and has an important role in assessing and diagnosing activity of RA. The invention aims to apply the enzyme linked immunosorbent assay to detect the LBP level, diagnose RA and assess the disease activity.

Description

technical field [0001] The invention relates to genetic recombination engineering, in particular to the application of lipopolysaccharide binding protein. Specifically, the present invention relates to the detection of LBP in serum and synovial fluid of RA patients by ELISA, so as to prepare corresponding kits related to rheumatoid arthritis and provide a new pharmaceutical application of lipopolysaccharide-binding protein. Background technique [0002] Lipopolysaccharide binding protein (LBP) is mainly produced by hepatocytes (renal proximal tubule epithelial cells, alveolar wall type II cells can also be synthesized in a small amount) and mediates the binding of endotoxin to target cell receptors. Acute-phase stress response protein, which can significantly promote the combination of lipopolysaccharide (LPS) and CD14 (mCD14) on the surface of monocyte / macrophage membrane to form LPS-LBP-CD14 complex, which passes through the membrane of monocyte / macrophage The Toll-Like R...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/47A61K38/17A61P37/02A61P19/02A61P29/00G01N33/68
CPCA61K38/00C07K14/4713G01N33/6893G01N2333/47G01N2800/102G01N2800/24
Inventor 孙晓麟温雯栗占国
Owner PEOPLES HOSPITAL PEKING UNIV
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