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Porous Se-SiO2 nanoparticle as well as preparation method and application thereof

A nanoparticle, se-sio2 technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, sulfur/selenium/tellurium active ingredients, etc. multifunctional effect

Active Publication Date: 2015-11-25
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nano-selenium products synthesized by the existing nano-selenium preparation methods cannot effectively control the release of selenium, and the function is relatively single, so it is necessary to continue to explore the synthesis of nano-selenium products, which can truly realize the controlled release and multi-function of nano-selenium change

Method used

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  • Porous Se-SiO2 nanoparticle as well as preparation method and application thereof
  • Porous Se-SiO2 nanoparticle as well as preparation method and application thereof
  • Porous Se-SiO2 nanoparticle as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1)Cu 2-xSynthesis of Se: Put 49mg cuprous chloride in a three-necked flask, add 10mL oleic acid to form a solution A, put 79mg selenium powder in another three-necked flask, add 5mL oleic acid and 5mL oleylamine to form a B solution . Put the two three-neck flasks into the heating mantle, blow in nitrogen, stir, heat to 120°C, and keep the temperature for 20 minutes to remove the moisture and oxygen in the device. Then the B solution was heated to 280°C, kept for half an hour, and then cooled to 220°C. At the same time, the temperature of solution A was raised to 220°C. Draw 5mL of B solution with a syringe, inject it into 10mL of A solution, react for 5 minutes, and cool to room temperature. Add appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes. After washing three times with ethanol, 10 mL of n-hexane was added to obtain Cu 2-x Se n-hexane dispersion, standby;

[0031] (2) Take 5mL of Cu prepared in step (1) 2-x Add Se n-hexane...

Embodiment 2

[0034] (1)Cu 2-x Synthesis of Se: Put 49mg cuprous chloride in a three-necked flask, add 10mL oleic acid to form a solution A, put 79mg selenium powder in another three-necked flask, add 5mL oleic acid and 5mL oleylamine to form a B solution . Put the two three-neck flasks into the heating mantle, blow in nitrogen, stir, heat to 120°C, and keep the temperature for 20 minutes to remove the moisture and oxygen in the device. Then the B solution was heated to 280°C, kept for half an hour, and then cooled to 220°C. At the same time, the temperature of solution A was raised to 220°C. Draw 5mL of B solution with a syringe, inject it into 10mL of A solution, react for 5 minutes, and cool to room temperature. Add appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes. After washing three times with ethanol, 10 mL of n-hexane was added to obtain Cu 2-x Se n-hexane dispersion, standby;

[0035] (2) Take 5mL of the Cu prepared in (1) 2-x Add the Se n-he...

Embodiment 3

[0039] A kind of porous Se-SiO 2 Nanoparticles, including elemental Se, SiO coated with elemental Se 2 and coated in SiO 2 Surface polyvinylpyrrolidone, its preparation method comprises the following steps:

[0040] (1) Nano Cu 2-x Synthesis of Se: Put 49mg cuprous chloride in a three-necked flask, add 10mL oleic acid to form a solution A, put 79mg selenium powder in another three-necked flask, add 5mL oleic acid and 5mL oleylamine to form a B solution . Put the two three-neck flasks into the heating mantle, feed nitrogen, stir, heat to 120°C, keep warm for 20 minutes, then heat solution B to 280°C, keep warm for half an hour, then cool it down to 220°C, at the same time, The temperature of solution A was raised to 220°C. Take 5mL of solution B and add it to 10mL of solution A, react for 5min, then cool to room temperature, add an appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes, wash the centrifuged product with ethanol three times, add ...

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Abstract

The invention relates to a porous Se-SiO2 nanoparticle as well as a preparation method and application thereof. The porous Se-SiO2 nanoparticle consists of elementary Se, SiO2 covering the elementary Se and polyvinylpyrrolidone covering the surface of the SiO2; the preparation method comprises the following steps: firstly preparing a Cu2-xSe normal hexane dispersion liquid, and then adding de-ionized water, n-hexanol, polyethylene glycol octylphenol ether, n-hexane, tetraethyl orthosilicate and ammonia water to the Cu2-xSe normal hexane dispersion liquid; dispersing a reaction product in the de-ionized water so as to obtain a nano Se-SiO2 dispersion liquid, then adding polyvinylpyrrolidone to the nano Se-SiO2 dispersion liquid and conducting hydrothermal treatment for a certain duration so as to obtain the porous Se-SiO2 nanoparticle; and the prepared porous Se-SiO2 nanoparticle can be applied to the loading, transfer or slow release of anti-cancer drugs. Compared with the prior art, the porous Se-SiO2 nanoparticle disclosed by the invention has the advantages of good biocompatibility, good nano Se release performance, high anti-cancer drug loading rate and the like.

Description

technical field [0001] The present invention relates to a kind of nano particle and its preparation method and application, especially to a kind of porous Se-SiO 2 Nanoparticles and methods for their preparation and applications. Background technique [0002] Selenium is one of the essential trace elements for the human body. Studies have shown that the lack of selenium in the human body can easily lead to more than 40 kinds of diseases, such as cancer, heart disease, diabetes, hypertensive metabolic disease and hepatitis. Adequate intake of selenium has the effects of enhancing the body's immunity and delaying biological aging. However, the safety limit of selenium between the optimal concentration and the toxic concentration is very narrow, so it is very important to develop low-toxic and high-efficiency selenium sources for human health. Compared with other states of selenium, the small size effect of nano-selenium particles makes them have optoelectronic properties tha...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K47/32A61K47/04A61K47/02A61P35/00
Inventor 刘锡建陆杰孙彦刚张丽娟张红徐菁利
Owner SHANGHAI UNIV OF ENG SCI
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