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A preparation method of hydrophobic microsphere toughened and enhanced physically cross-linked double network hydrogel

A technology of hydrophobic microspheres and physical enhancement, which is applied in the synthesis and toughening of hydrogels to achieve the effects of strong hydrophobic association, widening application fields and large specific surface area.

Inactive Publication Date: 2017-02-22
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrophobic microspheres used in the present invention toughen and strengthen the physical cross-linked double-network hydrogel to overcome the low strength of the physical cross-linked double-network hydrogel, so that the toughness and strength of the hydrogel are improved, and no related hydrophobic microspheres are found Toughened and enhanced physical cross-linked double network hydrogel report

Method used

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  • A preparation method of hydrophobic microsphere toughened and enhanced physically cross-linked double network hydrogel
  • A preparation method of hydrophobic microsphere toughened and enhanced physically cross-linked double network hydrogel

Examples

Experimental program
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Embodiment 1

[0020] (1) Preparation of hydrophobic microsphere emulsion

[0021] a. Prepare the first pre-emulsion

[0022] Mix water, comonomer I, emulsifier, initiator, crosslinking agent, molecular weight regulator and pH buffer according to the mass ratio of 100:60:6:0.1:0.2:0.01:0.1 to obtain the first pre-emulsification Liquid; The comonomer I is butyl acrylate, the emulsifier is sodium dodecyl sulfonate, the initiator is potassium persulfate, the crosslinking agent is divinylbenzene, and the molecular weight regulator is tertiary dodecyl mercaptan , pH value buffering agent is sodium bicarbonate;

[0023] b. Put the first pre-emulsion into the four-port reactor, put the four-port reactor into the constant temperature water tank, stir and feed nitrogen into the system, keep the temperature at 50°C, and wait for the air in the system to be emptied Afterwards, heat up to 70°C, keep warm for 2-4 hours, and the polymerization reaction is completed to obtain a hydrophobic microsphere em...

Embodiment 2

[0044] (1) Preparation of hydrophobic microsphere emulsion

[0045] a. Prepare the first pre-emulsion

[0046] Mix water, comonomer I, emulsifier, initiator, cross-linking agent, molecular weight regulator and pH buffer according to the mass ratio of 100:65:7:0.3:0.4:0.03:0.3 to obtain the first pre-emulsification Liquid; The comonomer I is butyl acrylate, the emulsifier is sodium dodecyl sulfonate, the initiator is potassium persulfate, the crosslinking agent is divinylbenzene, and the molecular weight regulator is tertiary dodecyl mercaptan , pH value buffering agent is sodium bicarbonate;

[0047] b. Put the first pre-emulsion into the four-port reactor, put the four-port reactor into the constant temperature water tank, stir and feed nitrogen into the system, keep the temperature at 50°C, and wait for the air in the system to be emptied Afterwards, heat up to 70°C, keep warm for 2-4 hours, and the polymerization reaction is completed to obtain a hydrophobic microsphere e...

Embodiment 3

[0059] (1) Preparation of hydrophobic microsphere emulsion

[0060] a. Prepare the first pre-emulsion

[0061] Mix water, comonomer I, emulsifier, initiator, cross-linking agent, molecular weight regulator and pH buffer according to the mass ratio of 100:70:8:0.5:0.6:0.05:0.5 to obtain the first pre-emulsification Liquid; The comonomer I is butyl acrylate, the emulsifier is sodium dodecyl sulfonate, the initiator is potassium persulfate, the crosslinking agent is divinylbenzene, and the molecular weight regulator is tertiary dodecyl mercaptan , pH value buffering agent is sodium bicarbonate;

[0062] b. Put the first pre-emulsion into the four-port reactor, put the four-port reactor into the constant temperature water tank, stir and feed nitrogen into the system, keep the temperature at 50°C, and wait for the air in the system to be emptied Afterwards, heat up to 70°C, keep warm for 2-4 hours, and the polymerization reaction is completed to obtain a hydrophobic microsphere e...

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Abstract

The invention provides a preparation method of hydrophobic microsphere toughened and reinforced physical crosslinking double-network hydrogel. The hydrophobic microsphere toughened and reinforced physical crosslinking double-network hydrogel consists of a first network and a second network by interpenetration, wherein the first network has a double-helix structure formed by gelatin macromolecular chains by virtue of hydrogen bond interaction; and the second network is a micelle which takes hydrophobic microspheres as a center and is formed by hydrophobic monomers in a copolymer of a co-monomer II namely acrylamide and a hydrophobic monomer namely hexadecyl methacrylate under the action of an emulsifier. The hydrophobic monomers and the hydrophobic microspheres in the hydrogel have a relatively strong hydrophobic association action, so that the elongation at break of the hydrogel reaches up to 6000%, the tensile strength reaches up to 2MPa, the mechanical properties of the hydrogel are improved, and the application field of the hydrogel is broadened.

Description

technical field [0001] The invention belongs to the synthesis and strengthening and toughening technology of hydrogel, and relates to a preparation method of hydrophobic microsphere toughening and strengthening physical crosslinking double network hydrogel. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network cross-linked structure. Since the molecular structure is mainly hydrophilic macromolecules, it can absorb a large amount of water. Hydrogels are soft, similar to living tissue materials, and have good biocompatibility, so they are widely used in tissue engineering, drug sustained release agents, tissue scaffold materials, etc. However, most hydrogels are limited in some application fields that require high toughness and high strength hydrogels due to their poor mechanical properties, such as tendon and cartilage. Many scholars in China are committed to the improvement and improvement of the mechanical properties of hydrogels. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/18C08F212/36C08F220/56C08F2/26C08J3/24C08J3/075
Inventor 任秀艳高光辉刘柏军刘辉
Owner CHANGCHUN UNIV OF TECH