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Extract method and application for plant composition containing vaccinium vitis-idaea

An extraction method and composition technology, which are applied in the field of extracting bilberry-containing plant compositions, can solve the problems of large patient dosage, many impurities, rough process and the like, and achieve the effect of reducing the dosage

Inactive Publication Date: 2015-12-02
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing bilberry. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • Extract method and application for plant composition containing vaccinium vitis-idaea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 100 parts of bilberry, 50 parts of Shuihuanglian, 60 parts of Jianxuezhu, 70 parts of Artemisia chinensis, and 50 parts of Daweisha, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, extract twice, 4-8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, and recover under reduced pressure Ethanol, concentrated and dried to obtain a microwave extract, and prepared into tablets with conventional excipients, each tablet 0.4g.

Embodiment 2

[0016] Take 100 parts of bilberry, 50 parts of Shuihuanglian, 60 parts of Jianxuezhu, 70 parts of Artemisia chinensis, and 50 parts of Daweisha, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, extract twice, 4-8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, and recover under reduced pressure Ethanol, concentrated and dried to obtain a microwave extract, which is prepared into capsules with conventional auxiliary materials.

Embodiment 3

[0018] Take 100 parts of bilberry, 50 parts of Shuihuanglian, 60 parts of Jianxuezhu, 70 parts of Artemisia chinensis, and 50 parts of Daweisha, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, extract twice, 4-8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, and recover under reduced pressure Ethanol, concentrated and dried to obtain a microwave extract, which is prepared into granules by adding conventional auxiliary materials.

[0019] Bilberry (scientific name: Vaccinium Vitis-Idaea) is a Rhododendronaceae plant, native to North America, an evergreen dwarf shrub. Mostly born in alpine tundra belt, single leaves alternate, obovate leaves, 2-8 flowers, bracts red, broad ovate, corolla white or light red, bell-shaped, about 5 mm long, 4-lobed, very short filaments...

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Abstract

The invention provides an extract method for a plant composition containing vaccinium vitis-idaea. The plant composition is prepared from the following crude drugs through a microwave extraction method: 100 parts of vaccinium vitis-idaea, 50 parts of radix thalictri simplicis, 60 parts of whole herb of lysimachia klattiana, 70 parts of root of meconopsis chelidonifolia and 50 parts of heliotropium indicum, so that the content is increased greatly and the dosage is reduced. The invention further provides application of the plant composition containing vaccinium vitis-idaea to preparation of drugs for inhibiting BV-2 cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an extraction method and application of a plant composition containing bilberry. Background technique [0002] The botanical composition containing bilberry is made of 100 parts of bilberry, 50 parts of Shuihuanglian, 60 parts of Jianxuezhu, 70 parts of Artemisia chinensis, and 50 parts of Daweisha. The current extraction method is to add water to decoct for two Once, each time for 2-3 hours, the decoction was combined, filtered, concentrated into a thick paste, granulated, dried, coated with sugar, and obtained. [0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing bilberry. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected ...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P35/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH