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Chinese traditional medicine preparation of licorice and sophora alopecuroides spray and preparation method thereof

The technology of a traditional Chinese medicine preparation and spray, which is applied in the field of traditional Chinese medicine, can solve the problems of aggravation of disease, unsuitable long-term use, inducing erythroderma, etc., and achieves the effects of low cost, improvement of skin itching, and significant clinical efficacy.

Inactive Publication Date: 2015-12-09
BAOTOU CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine mostly uses antihistamines, and in severe cases, hormones and immunosuppressants are used. These drugs have certain side effects and should not be taken for a long time
In particular, if hormones are used improperly, it can induce erythroderma, aggravate the disease, and cause physical and mental harm to patients and their families, and inevitably bring negative impacts to society

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Remove impurities from licorice and bitter beans, wash them, and dry them at a low temperature of 50-60°C;

[0021] (2) Glycyrrhizae, crushed, reflux extracted with 10 times the amount of 70% (v / v) ethanol twice, each time for 1.5h, combined the extracts, and filtered;

[0022] (3) Ethanol is recovered from the above solution, and concentrated to a crude drug amount of 0.8g / ml;

[0023] (4) Adsorb on the AB-8 and D101 (1:1) mixed resin column at a rate of 5 times the column volume / hour;

[0024] (5) Wash 1 times the volume of the column with purified water, backwash with 2.5 times the volume of the column with 80% (v / v) ethanol, recover the ethanol solution, and concentrate to a relative density of 1.11g / cm 3 (20°C), licorice extract;

[0025] (6) Broken the bitter beans, soaked in 15 times the amount of 75% (v / v) ethanol for 5 hours, at a temperature of 50-60°C, and filtered;

[0026] (7) Recover ethanol from the above bitter bean solution and concentrate to a r...

Embodiment 2

[0029] (1) Remove impurities from licorice and bitter beans, wash them, and dry them at a low temperature of 50-60°C;

[0030] (2) Glycyrrhizae, crushed, reflux extracted with 6 times the amount of 70% (v / v) ethanol twice, each time for 1.5h, combined extracts, filtered,

[0031] (3) Ethanol is recovered from the above solution, and concentrated to a crude drug amount of 0.8g / ml;

[0032] (4) Adsorb on AB-8 and D101 (1:1) mixed resin column at a rate of 3 times the column volume / hour;

[0033] (5) Wash 1 times the volume of the column with purified water, backwash with 2.5 times the volume of the column with 80% (v / v) ethanol, recover the ethanol solution, and concentrate to a relative density of 1.11g / cm 3 (20°C), licorice extract;

[0034] (6) Broken the bitter beans, soaked in 15 times the amount of 75% (v / v) ethanol for 5 hours, at a temperature of 50-60°C, and filtered;

[0035] (7) Recover ethanol from the above bitter bean solution and concentrate to a relative densi...

Embodiment 3

[0038] (1) Remove impurities from licorice and bitter beans, wash them, and dry them at a low temperature of 50-60°C;

[0039] (2) Glycyrrhizae, crushed, refluxed with 8 times the amount of 70% (v / v) ethanol for 2 times, each time for 1.5h, combined the extracts, filtered,

[0040] (3) Ethanol is recovered from the above solution, and concentrated to a crude drug amount of 0.8g / ml;

[0041] (4) Adsorb on the AB-8 and D101 (1:1) mixed resin column at a rate of 5 times the column volume / hour;

[0042] (5) Wash 1 times the volume of the column with purified water, backwash with 2.5 times the volume of the column with 80% (v / v) ethanol, recover the ethanol solution, and concentrate to a relative density of 1.11g / cm 3 (20°C), licorice extract;

[0043] (6) Broken the bitter beans, soaked in 15 times the amount of 75% (v / v) ethanol for 5 hours, at a temperature of 50-60°C, and filtered;

[0044] (7) Recover ethanol from the above bitter bean solution and concentrate to a relative...

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Abstract

The invention relates to a Chinese traditional medicine preparation of a licorice and sophora alopecuroides spray and a preparation method thereof. The Chinese traditional medicine preparation is prepared from 10-89% of licorice, 10-89% of sophora alopecuroides and 0.1-2% of mint oil. The preparation method of the Chinese traditional medicine preparation comprises the following steps that impurities of the licorice and the sophora alopecuroides are removed, and the licorice and the sophora alopecuroides are cleaned and dried; the licorice is subjected to smashing and reflux extraction, ethyl alcohol is recovered, resin column adsorption is performed, and eluant is collected and concentrated; the sophora alopecuroides is soaked in the ethyl alcohol, and filtration, ethyl alcohol recovery and concentration are performed; the concentrated solution and the licorice extracting solution are mixed evenly, and ethyl alcohol liquid or water is added to obtain the Chinese traditional medicine preparation. The Chinese traditional medicine preparation has the advantages that research findings show that the Chinese traditional medicine preparation has the effects of relieving skin itch and treating skin diseases and eczema, the preparation method is convenient and quick to operate, low in cost and easy to implement, the shortcomings in the prior art are overcome, and a wider way is provided for development of the pharmaceutical industry.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation of sweet and bitter spray and a preparation method thereof. Background technique [0002] The incidence of eczema and allergic skin diseases is gradually increasing, basically accounting for more than 50% of outpatient cases in dermatology hospitals (up to 80% of daily outpatient visits). For eczema, which is prone to recurrence and has no effective cure, seek traditional Chinese medicine There are more and more healers. Western medicine mostly uses antihistamines, and in severe cases, hormones and immunosuppressants are used for treatment, and these drugs have certain side effects and should not be taken for a long time. In particular, if hormones are used improperly, they can induce erythroderma, aggravate the disease, cause physical and mental harm to patients and their families, and inevitably bring negative ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K9/12A61P17/00A61P17/04A61P37/08
Inventor 吴清贾金良杨丽
Owner BAOTOU CHINESE TRADITIONAL MEDICINE
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