The application of five-finger peach and its extract

A technology of five-finger peach and five-finger peach alcohol, which is applied to medical preparations containing active ingredients, drug combinations, plant raw materials, etc., and can solve the problems of no use of five-finger peach and no cosmetic whitening

Active Publication Date: 2019-05-28
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no record of beauty and whitening effects of Wuzhi Maotao in the records of traditional Chinese medicine, and there is no report on the use of Wuzhi Maotao as a tyrosinase inhibitor in the prior art, and there is no report of Wuzhi Maotao being used in whitening cosmetics

Method used

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  • The application of five-finger peach and its extract
  • The application of five-finger peach and its extract
  • The application of five-finger peach and its extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of the five-fingered peach extract of the present invention

[0033] Dry and crush 40g of Peach chinensis, mix with 400mL of 70v / v% ethanol solution, extract by ultrasonic for 0.5 hours, separate the crude extract, remove the solvent under reduced pressure, and obtain 2.6g of crude extract of Peach syringae.

[0034] Take 1.6g of the crude extract of Peach chinensis, dissolve it with deionized water, load it into the AB-8 resin-filled column, and use deionized water, 20v / v% ethanol, 40v / v% ethanol, 60v / v% ethanol, Gradient elution with 80v / v% ethanol and 95v / v% ethanol, collect the eluents of 60v / v% ethanol, 80v / v% ethanol, and 95v / v% ethanol respectively, remove ethanol and water under reduced pressure, and obtain five-finger hair peach Extracts were collected and stored frozen at -20°C.

Embodiment 2

[0035] Embodiment 2: the preparation of the five-finger peach extract of the present invention

[0036]After drying 20g of Peach chinensis, crush it, mix it with 400mL of 50v / v% ethanol solution, stir and extract for 2 hours, separate the crude extract, remove the solvent under reduced pressure, and obtain 1.7g of crude extract of Peach syringae.

[0037] Take 1.0g of the crude extract of Prunus sinensis, dissolve it in deionized water, load it on a D301 resin-filled column, and sequentially elute it with deionized water, 40v / v% ethanol, 60v / v% ethanol, and 80v / v% ethanol , collect eluents of 60v / v% ethanol and 80v / v% ethanol respectively, and remove ethanol and water under reduced pressure to obtain the extract of Prunus chinensis, which is collected and stored frozen at -20°C.

Embodiment 3

[0038] Embodiment 3: the preparation of the five-fingered peach extract of the present invention

[0039] Dry and crush 40g of Peach chinensis, mix with 800mL of 90v / v% ethanol solution, extract in a countercurrent cycle for 1 hour, separate the crude extract, and remove the solvent under reduced pressure to obtain 1.9g of crude extract of Peach syringae.

[0040] Take 1.5g of the crude peach extract, dissolve it in deionized water, load it into the X-5 resin-filled column, and use deionized water, 30v / v% ethanol, 60v / v% ethanol, 90v / v% ethanol gradient For elution, collect eluents of 60v / v% ethanol and 90v / v% ethanol respectively, and remove ethanol and water under reduced pressure to obtain the extract of Peach chinensis, which is collected and stored frozen at -20°C.

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Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses application of radix fici simplicissimae and an extract thereof in preparing a tyrosinase inhibitor, a melanogenesis inhibitor, whitening cosmetics as well as in skin whitening and skin melanin deposition prevention. The radix fici simplicissimae and the extract thereof are excellent in tyrosinase inhibiting activity, and especially the radix fici simplicissimae extract is more significant in tyrosinase inhibiting activity compared with existing tyrosinase inhibitors and arbutin which serves as a whitening agent; and meanwhile, the radix fici simplicissimae and the extract thereof are effective in preventing melanin deposition and are relatively high in radical scavenging rate, and the radix fici simplicissimae and the extract thereof are relatively high in content of total flavonoids and are better applicable to the fields of beautifying and whitening.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to the new application of the five-fingered peach and its extract. Background technique [0002] Skin color is one of the criteria of people's aesthetics. For Asian women, fair complexion is a common pursuit. To this end, various products have emerged, such as: whitening products, UV protection products and film products. After research, skin color is determined comprehensively by various pigments contained in skin cells. Among the many pigments, the amount of melanin contained in melanocytes is the most important determinant. Further studies confirmed that tyrosinase (EC1.14.18.1) is a key enzyme for melanin synthesis. Therefore, by inhibiting the activity of tyrosinase, to reduce the production of melanin, so as to achieve the effect of whitening skin care has become one of the important basis for research and development of skin care products (Journal of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K36/60A61P17/00A61Q19/02
Inventor 方兆华沈忠海李慧
Owner JALA GROUP CORPORATION
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