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l‑threonine synthesis process

A synthesis process and threonine technology, applied in the field of L-threonine synthesis technology, can solve the problems of difficulty in realizing industrialized production, low yield, etc., and achieve the effects of improving utilization rate, reducing raw material cost, and simple and convenient process operation.

Active Publication Date: 2017-09-12
JIANGSU SKYRUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of these two methods is that the yield is low and it is difficult to realize industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] L-threonine synthesis process, with CH 2 CHCH(OH)CH 3 (3-buten-2-ol) as raw material, Cu 2 (OH) 2 CO 3 and CuCl 2 As a catalyst, after the double bond is epoxidized, under the action of the catalyst, it reacts with phCONCO to generate a five-membered heterocyclic compound. After diluting the solution, filter and remove Cu 2 (OH) 2 CO 3 and CuCl 2 Catalyst, acidification and ring opening to generate DL-threonine, and then split to obtain L-threonine.

[0017] Preferably, the mass ratio of the raw material to the catalyst is 100:0.2.

[0018] Among them, preferably, the Cu 2 (OH) 2 CO 3 with CuC1 2 The mass ratio is 1:1.

[0019] Among them, preferably, the Cu 2 (OH) 2 CO 3 The purity is 99.9%.

[0020] Among them, preferably, the CuCl 2 The purity is 99.9%.

[0021] The productive rate of L-threonine in this embodiment is shown in Table 1.

Embodiment 2

[0023] The specific steps are as in Example 1, wherein preferably, the mass ratio of the raw material to the catalyst is 100:0.1. The Cu 2 (OH) 2 CO 3 with CuCl 2 The mass ratio is 1:1.2. The Cu 2 (OH) 2 CO 3 The purity is 99.5%, the CuCl 2 The purity is 99.5%. The productive rate of L-threonine in this embodiment is shown in Table 1.

Embodiment 3

[0025] The specific steps are as in Example 1, wherein preferably, the mass ratio of the raw material to the catalyst is 100:0.05. The Cu 2 (OH) 2 CO 3 with CuCl 2 The mass ratio is 1:0.8. The Cu 2 (OH) 2 CO 3 The purity is 99.9%, the CuCl 2 The purity is 99.9%. The productive rate of L-threonine in this embodiment is shown in Table 1.

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PUM

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Abstract

The invention discloses a novel L-threonine synthetic process. According to the process, CH2CHCH(OH)CH3(3-butene-2-alcohol) is taken as the raw material, Cu2(OH)2CO3 and CuC12 are taken as catalysts, double bonds react with phCONCO after being epoxidized under the action of the catalysts to generate a five-membered heterocyclic compound, acidification loop opening is conducted to generate DL-threonine, and separation is conducted to obtain L-threonine. The process is easy to operate, Cu2(OH)2CO3 and CuC12 are added to serve as catalysts under research on the basis that the original process conditions are unchanged, the utilization rate of raw materials is increased greatly, raw material cost is effectively reduced, the yield of L-threonine is increased to 83% and is far higher than that of the existing process, and large-scale production is guaranteed for enterprises.

Description

technical field [0001] The invention belongs to the technical field of compound preparation, and in particular relates to a synthesis process of L-threonine. Background technique [0002] L-threonine is an essential amino acid, mainly used in medicine, chemical reagents, food fortifiers, feed additives, etc. In the pharmaceutical industry, L-threonine can be used to configure amino acid infusion and comprehensive amino acid preparations, and its iron salt can also be used in anti-anemia drugs. At the same time, L-threonine also has medicinal effects of promoting human development and anti-fatty liver. It is an intermediate for the manufacture of high-efficiency antibiotic monobactin, and is used in biochemical research. Clinically, L-threonine has the function of improving immunity. [0003] At present, there are reports on the synthesis process of L-threonine at home and abroad, including biosynthesis, protein hydrolysis and chemical synthesis. Among them, the biosynthesi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/22C07C227/34C07C227/18
Inventor 燕立波燕立兵张明鹤唐彦
Owner JIANGSU SKYRUN PHARMA CO LTD
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