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Application of Hypodematine in preparation of drugs resistant to human body fungi

An antifungal and drug technology for human body, applied in the field of compounds, can solve the problems of strong accumulation of toxicity, irritation, dizziness, allergy, etc., and achieve the effect of strong antifungal activity in human body and outstanding substantive characteristics.

Inactive Publication Date: 2016-01-27
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with a unique mechanism of action has become one of the hot spots in drug research and development today

Method used

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  • Application of Hypodematine in preparation of drugs resistant to human body fungi
  • Application of Hypodematine in preparation of drugs resistant to human body fungi
  • Application of Hypodematine in preparation of drugs resistant to human body fungi

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of compound Hypodematine tablet involved in the present invention:

[0012] Take 5 grams of the compound Hypodematine, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Hypodematine capsules involved in the present invention:

[0014] Take 5 grams of the compound Hypodematine, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0016] Experimental example 1: Hypodematine anti-fungal activity in humans

[0017] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of Hypodematine is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the equal volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the culture temperature of human fungi is respectively 28°C, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the anti-human fungus results of Hypodematine are shown in Table 1.

[0018] Table 1 Hypodematine anti-human ...

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Abstract

The invention relates to an application of Hypodematine in the preparation of drugs resistant to human body fungi and belongs to the field of medicine. Hypodematine is highly inhibitory on Trichophyton rubrum, Microsporum lanosum or Trichophyton tonsurans, thus Hypodematine can serve as a compound resistant to human body fungi and is expected to be applied in the preparation of related drugs.

Description

technical field [0001] The present invention relates to a new application of the compound Hypodematine, in particular to the application of Hypodematine in the preparation of antifungal drugs for human body. Background technique [0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with unique mechanism of action has become one of the hot spots in drug research and development today. [0003] The compound Hypodematine involved in the present invention is a new compound published in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/395A61P31/10
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD