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Application of sulphur in preparation of composition for inhibiting tumors

A technology of composition and use, applied in the field of biological sciences, which can solve the problems of complex drug delivery components and other problems

Inactive Publication Date: 2016-02-03
SHANGHAI INST OF PLANNED PARENTHOOD RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The administration components of traditional Chinese medicine are relatively complex. At present, few studies have focused on the function of a single component of traditional Chinese medicine. Therefore, exploring the role and mechanism of a single component of traditional Chinese medicine in cancer treatment is of great significance for the research of anti-tumor drugs.

Method used

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  • Application of sulphur in preparation of composition for inhibiting tumors
  • Application of sulphur in preparation of composition for inhibiting tumors
  • Application of sulphur in preparation of composition for inhibiting tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1, establishment of nude mouse model

[0095] Several weeks (DU145, SW620) or several days (22RV1) after the tumor cells were inoculated into the neck and back of nude mice, tiny tumors grew, such as figure 1 .

Embodiment 2

[0096] Embodiment 2, SW620 tumor test result

[0097] The tumor growth of the nude mice in the sulfur intake group was significantly inhibited, and with the prolongation of the sulfur intake time, the inhibitory effect was more obvious, and the inhibition rate was 57.57% at the end of the experiment, P=0.0236, as figure 2 .

Embodiment 3

[0098] Embodiment 3, DU145 tumor experiment result

[0099] Different doses of sulfur intake can inhibit the growth of DU145 tumors, such as image 3 .

[0100] The tumor of nude mice of 20mg / d dosage group is subjected to the most obvious suppression (67.8%), obviously higher than 40mg (29.4%), as image 3 Shown in B.

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Abstract

The invention belongs to the field of biotechnology, and relates to application of sulphur in preparation of composition for inhibiting tumors. The fact that the sulphur can obviously inhibit the tumors, particularly colon cancer or prostatic cancer, is disclosed for the first time, multiplication rate can be reduced obviously, and therefore, the sulphur can serve as an effective drug ingredient for treating the tumors.

Description

technical field [0001] The invention belongs to the technical field of biological science; more specifically, the invention relates to the use of sulfur in the preparation of a composition for inhibiting tumors. Background technique [0002] With the improvement of human living standards, great changes have taken place in the living environment of human beings, various carcinogenic factors are increasing, and various tumors have become the number one factor that affects the quality of human life and threatens human life and health. Colon cancer is one of the common malignant tumors, accounting for 10-15% of all malignant tumors. Prostate cancer is the most common malignant tumor of the male genitourinary system, with the most in European and American countries. Now, the increase of the incidence rate of prostate cancer in our country also ranks first in various tumors. Early prostate cancer is mostly androgen-dependent, and hormone-blocking therapy is generally used. Howev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A23L1/29A61P35/00
Inventor 李润生陈海林李玉华段斐陈良康陈建兴
Owner SHANGHAI INST OF PLANNED PARENTHOOD RES
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