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Method for treating titanium dioxide nanotubes with curcumin derivatives

A curcumin derivative, titanium dioxide technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry and other directions, can solve the problems of patient danger, environmental pollution, poor water solubility, etc., and achieve long-lasting antibacterial effect, good antibacterial ability and Anticancer ability, effect of simple preparation method

Active Publication Date: 2018-04-06
成都植宇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the water solubility of curcumin derivatives is relatively poor. If the curcumin derivatives are directly introduced into the surface of titanium dioxide nanotubes, more organic solvents need to be used, which will pollute the environment, and there may be solvent residues on the titanium dioxide nanotubes, which is harmful to patients. create danger

Method used

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  • Method for treating titanium dioxide nanotubes with curcumin derivatives
  • Method for treating titanium dioxide nanotubes with curcumin derivatives
  • Method for treating titanium dioxide nanotubes with curcumin derivatives

Examples

Experimental program
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Embodiment 1

[0024] This program utilizes curcumin derivatives to process the method for titanium dioxide nanotubes, comprising the following steps:

[0025] 1) Dissolve 3 parts by weight of p-hydroxybenzaldehyde in 7 parts by weight of ethyl acetate, add 1 part by weight of 4-nitrobenzyl chloride, control 70 ° C, stir for 2 hours, and obtain a compound with formula (1), which is p-(4-nitrobenzyloxy)benzaldehyde;

[0026]

[0027] 2) Dissolve 2 parts by weight of p-(4-nitrobenzyloxy)benzaldehyde and 2 parts by weight of tributyl borate in 3 parts by weight of ethyl acetate, stir at room temperature for 5 minutes, add 0.5 parts by weight of acetylacetone and oxidize For the mixed solution of 0.5 parts by weight of boron, continue to stir at room temperature for 25 minutes, add 0.5 parts by weight of n-butylamine, continue to stir for 4 hours, then stop stirring and let it stand for 12 hours, then add 6 parts by weight of hydrochloric acid with a concentration of 0.4mol / L, and control the...

Embodiment 2

[0033] This program utilizes curcumin derivatives to process the method for titanium dioxide nanotubes, comprising the following steps:

[0034] 1) Dissolve 2 parts by weight of p-hydroxybenzaldehyde in 5 parts by weight of ethyl acetate, add 1 part by weight of 4-nitrobenzyl chloride, control 60 ° C, stir for 2 hours, and obtain a compound with formula (1), which is p-(4-nitrobenzyloxy)benzaldehyde;

[0035]

[0036] 2) Dissolve 1 part by weight of p-(4-nitrobenzyloxy)benzaldehyde and 1 part by weight of tributyl borate in 2 parts by weight of ethyl acetate, stir at room temperature for 3 minutes, then add 0.2 part by weight of acetylacetone and oxidize 0.1 parts by weight of boron mixed solution, continue to stir at room temperature for 20 minutes, add 0.2 parts by weight of n-butylamine, continue to stir for 3 hours, then stop stirring and let stand for 12 hours, then add 5 parts by weight of hydrochloric acid with a concentration of 0.4mol / L, and control the temperature...

Embodiment 3

[0042] This program utilizes curcumin derivatives to process the method for titanium dioxide nanotubes, comprising the following steps:

[0043] 1) Dissolve 5 parts by weight of p-hydroxybenzaldehyde in 10 parts by weight of ethyl acetate, add 3 parts by weight of 4-nitrobenzyl chloride, control 80 ° C, stir for 3 hours, and obtain a compound with formula (1), namely p-(4-nitrobenzyloxy)benzaldehyde;

[0044]

[0045] 2) Dissolve 4 parts by weight of p-(4-nitrobenzyloxy)benzaldehyde and 4 parts by weight of tributyl borate in 8 parts by weight of ethyl acetate, stir at room temperature for 7 minutes, add 1 part by weight of acetylacetone and oxidize For the mixed solution of 0.8 parts by weight of boron, continue to stir at room temperature for 30 minutes, then add 1 part by weight of n-butylamine, continue to stir for 5 hours, then stop stirring and let it stand for 18 hours, then add 10 parts by weight of hydrochloric acid with a concentration of 0.4mol / L, and control the...

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Abstract

The invention discloses a method for treatment of titanium dioxide nanotubes with a curcumin derivative. The method includes the steps of: 1) preparing a curcumin derivative; 2) dissolving 0.1-0.6 part by weight of cyclodextrin in 3.5-20 parts by weight of water, stirring the materials evenly, adding 0.5-1.5 parts by weight of titanium dioxide nanotubes, and performing soaking for 20-60min; 3) adding 0.2-1.2 parts by weight of the curcumin derivative, then using 15-30kHz ultrasonic wave to perform treatment for 30-60min; and 4) taking out the titanium dioxide nanotubes and conducting drying. Through the effect of cyclodextrin and the curcumin derivative on titanium dioxide nanotubes, the titanium dioxide nanotubes have good antibacterial and anticancer properties, and the surfaces of the titanium dioxide nanotubes can be beneficial to the growth of bone cells, the complication incidence of titanium dioxide nanotubes in osseointegration operations can be reduced, and safer and more reliable materials can be provided to osseointegration operations.

Description

technical field [0001] The invention relates to the technical field of titanium dioxide nanotubes in osseointegration operations, more specifically a method for treating titanium dioxide nanotubes with curcumin derivatives. Background technique [0002] α-cyclodextrin is a class of macrocyclic compounds formed by connecting six D-glucopyranose units end-to-end through α-1,4 glycosidic bonds. Inside the molecule is a "V"-shaped hydrophobic cavity, showing a unique molecular recognition ability. Titanium dioxide nanotubes can promote the formation of osteoblasts, and have shown great potential and advantages in the application of implants. However, a serious problem is the associated bacterial infection problem, which leads to the failure of a large number of transplant operations. Recently, researchers have focused on improving the antibacterial and other capabilities of titanium dioxide nanotubes. How to obtain titanium dioxide nanotube materials with better properties ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/02A61L27/54C07C205/34C07C201/12
Inventor 李培源苏炜霍丽妮陈睿
Owner 成都植宇生物科技有限公司
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