A kind of tilmicosin drug inclusion compound and its preparation and application

Abstract

The invention relates to a drug inclusion compound of tilmicosin and its preparation and application. In the preparation method, the insoluble tilmicosin drug is first loaded onto nano-silica, and by adjusting the amount of tilmicosin and nano-silica sol in the preparation process of the inner core particles, a compound accounting for 80% of the total weight of the drug 90% of the inner core particles loaded with tilmicosin; and then coated with a coating solution made of resin, talcum powder, alcohol, surfactant, etc., to obtain the tilmicosin drug inclusion compound. After the drug inclusion compound is loaded with nano-silica, the drug concentration in saliva is reduced. At the same time, the drug-loaded particles are coated by inclusion technology, which not only achieves double taste-masking effects, but also plays a role in sustained release. role. In addition, the process of preparing the coating liquid in the present invention is simple, and after the coating is completed, the alcohol evaporates after being dried, so that the ingredients contained in the coating can be reduced without changing the coating effect.

Description

technical field [0001] The invention belongs to the technical field of veterinary biological products, and relates to a drug inclusion compound of tilmicosin and its preparation and application. Background technique [0002] Tilmicosin is a semi-synthesized macrolide antibiotic for livestock and poultry, which is a hydrolyzate of tylosin. The raw material drug is insoluble in water, has inhibitory effect on all Gram-positive bacteria, some Gram-negative bacteria, spirochetes, mycoplasma, mycoplasma, etc., has a wide antibacterial spectrum, strong antibacterial activity, and pathogens have low resistance to it ,, the drug has been approved for clinical use in Australia, Spain, the United States, France, Brazil, Malaysia, Italy and other countries. It mainly treats animal infectious diseases such as goats, dairy cows, pigs, and chickens, especially respiratory diseases. Actinobacillus, Pasteurella, have stronger antibacterial activity than tylosin. [0003] Tilmicosin is adm...

AI Technical Summary

Problems solved by technology

However, the first method often uses technical means such as phase separation, spray drying, and double emulsion technology, and many accompanying problems, such as the use of toxic solvents, high temperature, strong acid and alkali, etc., can cause the decomposition of drugs

The second loading method is to divide the drug loading and the preparation of carrier particles into two steps, so the above-mentioned problems are avoided, but the drug loading amount in the medicament prepared by the second loading method is low, and the above two loading methods are currently The raw materials used in the method are all more, and the preparation process is also comparatively complicated

[0012] The above two methods use more raw materials for the preparation of core granules, and the preparation of coating liquid has more raw materials and the preparation process is complicated.

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