High-temperature regeneration method of column chromatography silica gel

A column chromatography and silica gel technology, applied in separation methods, filter regeneration, chemical instruments and methods, etc., can solve problems such as high cost, unqualified silica gel quality, complexity, etc., and achieve low production cost, less pollution, and simple operation Effect

Inactive Publication Date: 2016-02-10
CHONGQING ZHENYUAN HONGDOUSHAN DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Column chromatography silica gel absorbs moisture or other organic impurities in the medium during use. When the adsorption effect cannot meet the purification and separation requirements, different methods can be used to regenerate it and reu

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example 1:

[0023] A method for high-temperature regeneration of column chromatography silica gel, which is characterized in that it is carried out according to the following steps:

[0024] a. After loading the regenerated silica gel with a tray, put it into a trolley-type electric furnace with a charging thickness of 3.8 cm. The silica gel will be regenerated and activated at 570°C, and it will take 3 hours;

[0025] b. After the end, drive out the trolley, discharge the material in time, and reload the silica gel to be regenerated;

[0026] c. Cool the regenerated silica gel for 2 hours, and the air humidity during cooling is 45-65%. After cooling, white regenerated silica gel is obtained. After testing, it meets the requirements of chromatography silica gel standards.

Example Embodiment

[0027] Example 2:

[0028] A method for high-temperature regeneration of column chromatography silica gel, which is characterized in that it is carried out according to the following steps:

[0029] a. After loading the regenerated silica gel with a tray, put it into a trolley-type electric furnace with a thickness of 3.0cm. The silica gel is regenerated and activated at 570°C, and it takes 2.5h;

[0030] b. After the end, drive out the trolley, discharge the material in time, and reload the silica gel to be regenerated;

[0031] c. Cool the regenerated silica gel for 2.2 hours, and the air humidity during cooling is 45-65%. After cooling, white regenerated silica gel is obtained. After testing, it meets the requirements of chromatography silica gel standards.

Example Embodiment

[0032] Example 3:

[0033] A method for high-temperature regeneration of column chromatography silica gel, which is characterized in that it is carried out according to the following steps:

[0034] a. After loading the regenerated silica gel with a tray, put it into a trolley-type electric furnace with a charging thickness of 2.0cm. The silica gel is regenerated and activated at 570°C, and it takes 3.5h;

[0035] b. After the end, drive out the trolley, discharge the material in time, and reload the silica gel to be regenerated;

[0036] c. Cool the regenerated silica gel for 1.8 hours, and the air humidity during cooling is 45-65%. After cooling, white regenerated silica gel is obtained. After testing, it meets the requirements of chromatography silica gel standards.

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PUM

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Abstract

The invention discloses a high-temperature regeneration method of column chromatography silica gel. The high-temperature regeneration method comprises the following steps: a, after loading a tray with silica gel to be regenerated, putting the tray into a car-type electric furnace, and regenerating and activating the silica gel at the temperature of 570 DEG C, wherein the loading thickness is smaller than or equal to 4 cm; b, after the regeneration and activation are over, driving out the car, unloading timely, and loading the car with silica gel to be regenerated again; c, cooling the regenerated silica gel at the air humidity of 45-65%, so as to obtain white regenerated silica gel after cooling. According to the high-temperature regeneration method of column chromatography silica gel, chromatography silica gel is a separation carrier which is used in the separation purification and production processes of Chinese herbal medicine, chemical synthetic drugs and bioactive substances in large quantities; the method is easy to operate, and the regenerated column chromatography silica gel conforms to reuse requirements, and is high in regeneration efficiency and low in production cost; pollution is reduced due to recycling, and the economic benefits are improved.

Description

technical field [0001] The invention belongs to the technical field of silica gel regeneration, and in particular relates to a column chromatography silica gel high-temperature regeneration method. Background technique [0002] The main component of column chromatography silica gel is silica, which has a certain pore distribution. At the same time, there are many silanol groups on the surface of the particles. The adsorption and retention time of different components in the mixture are different, which can make the mixed components of different substances reach The purpose of separation and purification. The main uses of chromatography silica gel are: [0003] <1> Used for the separation and purification of Chinese herbal medicines, chemically synthesized drugs and biologically active substances, such as paclitaxel, docetaxel, artemisinin, notoginseng saponins, coenzyme Q10 and other active drugs. [0004] <2> Prepare high-purity substances by adsorption and se...

Claims

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Application Information

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IPC IPC(8): B01J20/283B01J20/34
Inventor 徐道礼徐胜博雷茂林
Owner CHONGQING ZHENYUAN HONGDOUSHAN DEV CO LTD
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