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Application of nevirapine in preparing anti-inflammatory medicine

A nevirapine and medicine technology, which is applied in the application field of nevirapine in the preparation of medicines for preventing and treating inflammation-related diseases, can solve the problems of no nevirapine anti-inflammatory activity and anti-inflammatory target activity, etc., and achieves low price, high safety, The effect of promoting neutrophil regression

Inactive Publication Date: 2016-04-06
HANGZHOU LEISUO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there have been no relevant reports on the anti-inflammatory activity and anti-inflammatory target activity of nevirapine

Method used

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  • Application of nevirapine in preparing anti-inflammatory medicine
  • Application of nevirapine in preparing anti-inflammatory medicine
  • Application of nevirapine in preparing anti-inflammatory medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example Quantitative observation of the anti-inflammatory drug effect of a single concentration of nevirapine in a zebrafish inflammation model

[0020] Zebrafish:

[0021] The zebrafish used in this example was MPO-GFP zebrafish, and the breeding and use standards were strictly in accordance with the requirements of the American Laboratory Animal Care and Use Committee (IACUC).

[0022] Fishwater:

[0023] Configuration method: Add 0.3g of sea salt (InstantOceansalts) to 1L of reverse osmosis (RO) water.

[0024] Dimethyl sulfoxide (DMSO, analytically pure):

[0025] Purchased from Aladdin (Catalog #1095515, Lot #30573). 1% DMSO solution (negative control) preparation: When in use, prepare a working solution with a concentration of 1.0% with fish farming water, and prepare it immediately for use.

[0026] Copper Sulfate (Inducer):

[0027] Purchased from Xilong Chemical Co., Ltd., batch number 069H155. When in use, use 0.1% DMSO solution to prepare the concentrat...

Embodiment 2

[0042] Example 2 Quantitative observation of the anti-inflammatory drug effect of multi-concentration nevirapine in zebrafish inflammation model

[0043] The experimental method is the same as in Example 1. In a 12-well plate, 15 fish per well, 1ml of fish water, observe the anti-inflammatory drug effect of nevirapine in the copper sulfate-induced zebrafish inflammation model at 10, 30, and 100 μM concentrations, anti-inflammatory The therapeutic efficiencies were 20.3%, 36.8% (p<0.01), and 53.1% (p<0.01), and no toxic phenotype was observed in each concentration group, indicating that nevirapine had significant anti-inflammatory effects within non-toxic concentrations, and the amount Effective relationship is clear.

[0044] Table 2 Anti-inflammatory efficacy of nevirapine in copper sulfate-induced zebrafish inflammation model (mean±sem)

[0045]

[0046] Compared to the blank group, #, p p p <0.01.

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Abstract

The invention belongs to the technical field of medicine and particularly relates to an application of nevirapine in preparing medicine for preventing and treating inflammation related diseases. Inflammation is aseptic inflammation and immune inflammation. The application of nevirapine in preparing the anti-inflammatory medicine is disclosed for the first time. Through experiment research on a copper sulfate induced zebra fish inflammation model, the result shows that nevirapine can promote degradation of neutrophile granulocyte of inflammatory sites and has anti-inflammatory and inflammation diminishing effects. Thus, nevirapine has the obvious anti-inflammatory effect on the inflammation related diseases and can be used for preparing the medicine for preventing and treating the inflammation related diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of nevirapine in the preparation of medicines for preventing and treating inflammation-related diseases. Background technique [0002] Inflammation is a beneficial host response to invading pathogens or sterile tissue damage. Inflammatory response is a result of the joint action of cells and inflammatory mediators in time and space to neutralize or eliminate damage stimuli to maintain homeostasis. Although inflammation is primarily a physiological and beneficial process, unresolved inflammatory processes contribute to the development of many inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, asthma, psoriasis, systemic lupus erythematosus, multiple sclerosis , systemic vasculitis, atherosclerosis, rhinitis, etc. [0003] For the treatment of inflammation, glucocorticoid anti-inflammatory drugs (dexamethasone, prednisone,...

Claims

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Application Information

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IPC IPC(8): A61K31/551A61P19/02A61P29/00A61P1/04A61P13/08A61P11/02A61P11/04A61P1/18A61P11/06A61P17/06A61P25/00A61P37/02
Inventor 李春启周娟宋如顺高羽军吴耀东
Owner HANGZHOU LEISUO PHARMA
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